Immunotherapy for colorectal cancer: Mechanisms and predictive biomarkers

L Carlsen, KE Huntington, WS El-Deiry - Cancers, 2022 - mdpi.com
Simple Summary Late-stage colorectal cancer treatment often involves chemotherapy and
radiation that can cause dose-limiting toxicity, and therefore there is great interest in …

[HTML][HTML] Biomarkers of response and resistance to immunotherapy in microsatellite stable colorectal cancer: toward a new personalized medicine

N Huyghe, E Benidovskaya, P Stevens… - Cancers, 2022 - mdpi.com
Simple Summary Immune Checkpoint Inhibitors (ICIs) have demonstrated clinical efficacy in
Microsatellite Instability High Colorectal Cancer (MSI-H CRC). However, in Microsatellite …

Doxorubicin-sensitive and-resistant colorectal cancer spheroid models: assessing tumor microenvironment features for therapeutic modulation

R Valente, S Cordeiro, A Luz, MC Melo… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: The research on tumor microenvironment (TME) has recently been gaining
attention due to its important role in tumor growth, progression, and response to therapy …

Principles of molecular utility for CMS classification in colorectal cancer management

L Rejali, R Seifollahi Asl, F Sanjabi, N Fatemi… - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer is the second most deadly tumor worldwide, despite the
availability of screening plans and advanced treatment strategies. Molecular biomarkers …

Overcoming immunosuppression and pro-tumor inflammation in lung cancer with combined IL-1β and PD-1 inhibition

JM Lee, M Tsuboi, ES Kim, TSK Mok, P Garrido - Future Oncology, 2022 - Taylor & Francis
Inflammation in the tumor microenvironment is a complicit and known carcinogenesis driver.
Inhibition of IL-1β, one of the most abundant and influential cytokines in the tumor …

[HTML][HTML] Expression of immune-related and inflammatory markers and their prognostic impact in colorectal cancer patients

S An, SK Kim, HY Kwon, CS Kim, HJ Bang… - International journal of …, 2023 - mdpi.com
The tumor microenvironment of colorectal cancer (CRC) is heterogenous; thus, it is likely
that multiple immune-related and inflammatory markers are simultaneously expressed in the …

[HTML][HTML] Biomarkers to detect early-stage colorectal cancer

JI Keenan, FA Frizelle - Biomedicines, 2022 - mdpi.com
Colorectal cancer is a leading cause of mortality worldwide. The high incidence and the
acceleration of incidence in younger people reinforces the need for better techniques of …

Wavelet scattering networks in deep learning for discovering protein markers in a cohort of Swedish rectal cancer patients

TD Pham, XF Sun - Cancer Medicine, 2023 - Wiley Online Library
Background Cancer biomarkers play a pivotal role in the diagnosis, prognosis, and
treatment response prediction of the disease. In this study, we analyzed the expression …