Develo** bioorthogonal probes to span a spectrum of reactivities
SS Nguyen, JA Prescher - Nature Reviews Chemistry, 2020 - nature.com
Bioorthogonal chemistries enable researchers to interrogate biomolecules in living systems.
These reactions are highly selective and biocompatible, and can be performed in many …
These reactions are highly selective and biocompatible, and can be performed in many …
Constructing new bioorthogonal reagents and reactions
RD Row, JA Prescher - Accounts of chemical research, 2018 - ACS Publications
Conspectus Chemical tools are transforming our understanding of biomolecules and living
systems. Included in this group are bioorthogonal reagents–functional groups that are inert …
systems. Included in this group are bioorthogonal reagents–functional groups that are inert …
Catalytic activation of bioorthogonal chemistry with light (CABL) enables rapid, spatiotemporally controlled labeling and no-wash, subcellular 3D-patterning in live …
Described is the spatiotemporally controlled labeling and patterning of biomolecules in live
cells through the catalytic activation of bioorthogonal chemistry with light, referred to as …
cells through the catalytic activation of bioorthogonal chemistry with light, referred to as …
Imaging and editing the phospholipidome
DC Chiu, JM Baskin - Accounts of chemical research, 2022 - ACS Publications
Conspectus Membranes are multifunctional supramolecular assemblies that encapsulate
our cells and the organelles within them. Glycerophospholipids are the most abundant …
our cells and the organelles within them. Glycerophospholipids are the most abundant …
A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity
The fidelity of signal transduction requires spatiotemporal control of the production of
signaling agents. Phosphatidic acid (PA) is a pleiotropic lipid second messenger whose …
signaling agents. Phosphatidic acid (PA) is a pleiotropic lipid second messenger whose …
Installation of minimal tetrazines through silver-mediated Liebeskind–Srogl coupling with arylboronic acids
Described is a general method for the installation of a minimal 6-methyltetrazin-3-yl group
via the first example of a Ag-mediated Liebeskind–Srogl cross-coupling. The attachment of …
via the first example of a Ag-mediated Liebeskind–Srogl cross-coupling. The attachment of …
Fluorescence quenching effects of tetrazines and their Diels–Alder products: mechanistic insight toward fluorogenic efficiency
Abstract Inverse electron demand Diels–Alder reactions between s‐tetrazines and strained
dienophiles have numerous applications in fluorescent labeling of biomolecules. Herein, we …
dienophiles have numerous applications in fluorescent labeling of biomolecules. Herein, we …
Derivatization based on tetrazine scaffolds: synthesis of tetrazine derivatives and their biomedical applications
H Sun, Q Xue, C Zhang, H Wu, P Feng - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
Bioorthogonal chemistry is widely used in biological systems and has been trialed in
patients, attracting a lot of attention in this century. Tetrazine-based bioorthogonal reactions …
patients, attracting a lot of attention in this century. Tetrazine-based bioorthogonal reactions …
Spatiotemporal control of phosphatidic acid signaling with optogenetic, engineered phospholipase Ds
Phosphatidic acid (PA) is both a central phospholipid biosynthetic intermediate and a
multifunctional lipid second messenger produced at several discrete subcellular locations …
multifunctional lipid second messenger produced at several discrete subcellular locations …
Photochemical syntheses, transformations, and bioorthogonal chemistry of trans-cycloheptene and sila trans-cycloheptene Ag (I) complexes
A photochemical synthesis of AgNO3 complexes of trans-cycloheptene (TCH) and trans-1-
sila-4-cycloheptene (Si-TCH) derivatives is described. A low temperature flow photoreactor …
sila-4-cycloheptene (Si-TCH) derivatives is described. A low temperature flow photoreactor …