Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …

▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

Alternative RNA splicing plays an important role in cancer. To determine which factors
involved in RNA processing are essential in prostate cancer, we performed a genome-wide …

Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of
gene control in humans. It provides cells with the opportunity to create protein isoforms of …

Many DNA and RNA regulatory proteins contain polypeptide domains that are unstructured
when analyzed in cell lysates. These domains are typified by an over-representation of a …

Peroxisome proliferator-activated receptor α (PPARα) plays a key role in the transcriptional
control of genes encoding mitochondrial fatty acid β-oxidation (FAO) enzymes. In this study …

SR proteins constitute a family of pre-mRNA splicing factors now thought to play several
roles in mRNA metabolism in metazoan cells. Here we provide evidence that a prototypical …

The processing of pre-mRNAs is a fundamental step required for the expression of most
metazoan genes. Members of the family of serine/arginine (SR)-rich proteins are critical …

Recent years have witnessed significant advances in the understanding of the role of
ceramide in apoptosis. This review summarizes these recent findings and discusses insights …

Alternative splicing of mRNA precursors enables one gene to produce multiple protein
isoforms with differing functions. Under normal conditions, this mechanism is tightly …