MCP-1: Function, regulation, and involvement in disease

S Singh, D Anshita, V Ravichandiran - International immunopharmacology, 2021 - Elsevier
Abstract MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif)
ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of …

The role of inflammation in the pathogenesis of osteoarthritis

YY Chow, KY Chin - Mediators of inflammation, 2020 - Wiley Online Library
A joint is the point of connection between two bones in our body. Inflammation of the joint
leads to several diseases, including osteoarthritis, which is the concern of this review …

Monocytes, macrophages, and their potential niches in synovial joints–therapeutic targets in post-traumatic osteoarthritis?

P Haubruck, MM Pinto, B Moradi, CB Little… - Frontiers in …, 2021 - frontiersin.org
Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …

Biomechanics of chondrocytes and chondrons in healthy conditions and osteoarthritis: a review of the mechanical characterisations at the microscale

S Pettenuzzo, A Arduino, E Belluzzi, A Pozzuoli… - Biomedicines, 2023 - mdpi.com
Biomechanical studies are expanding across a variety of fields, from biomedicine to
biomedical engineering. From the molecular to the system level, mechanical stimuli are …

Contribution of infrapatellar fat pad and synovial membrane to knee osteoarthritis pain

E Belluzzi, E Stocco, A Pozzuoli… - BioMed research …, 2019 - Wiley Online Library
Osteoarthritis (OA) is the most common form of joint disease and a major cause of pain and
disability in the adult population. Interestingly, there are patients with symptomatic OA …

Infrapatellar fat pad gene expression and protein production in patients with and without osteoarthritis

E Belluzzi, V Macchi, CG Fontanella… - International journal of …, 2020 - mdpi.com
Osteoarthritis (OA) is one of the most common joint disorders. Evidence suggests that the
infrapatellar fat pad (IFP) is directly involved in OA pathology. However, a comparison …

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

Y Zu, Y Mu, Q Li, ST Zhang, HJ Yan - Journal of orthopaedic surgery and …, 2019 - Springer
Background Osteoarthritis (OA) is the common chronic degenerative joint bone disease that
is mainly featured by joint stiffness and cartilage degradation. Icariin (ICA), an extract from …

Meniscus regeneration by 3D printing technologies: Current advances and future perspectives

E Stocco, A Porzionato, E De Rose… - Journal of tissue …, 2022 - journals.sagepub.com
Meniscal tears are a frequent orthopedic injury commonly managed by conservative
strategies to avoid osteoarthritis development descending from altered biomechanics …

Tannic acid/Sr2+-coated silk/graphene oxide-based meniscus scaffold with anti-inflammatory and anti-ROS functions for cartilage protection and delaying …

Y Li, M Chen, J Yan, W Zhou, S Gao, S Liu, Q Li… - Acta biomaterialia, 2021 - Elsevier
Tissue engineering method provides a promising solution for meniscus repair and
regeneration. However, the inflammatory environment that persists after meniscus injury in …

CC chemokines and receptors in osteoarthritis: new insights and potential targets

Y Zhang, D Liu, DTA Vithran, BR Kwabena… - Arthritis Research & …, 2023 - Springer
Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of
innate and adaptive immune systems-associated inflammatory responses. Due to the local …