Neurodevelopmental disorders—high-resolution rethinking of disease modeling

K Khodosevich, CM Sellgren - Molecular Psychiatry, 2023 - nature.com
Neurodevelopmental disorders arise due to various risk factors that can perturb different
stages of brain development, and a combinatorial impact of these risk factors programs the …

Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity

D Chatterjee, JM Beaulieu - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of
lithium ions on mood regulation in bipolar disorder and other mental illnesses, including …

Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development

M Shen, CL Sirois, Y Guo, M Li, Q Dong… - Neuron, 2023 - cell.com
Fragile X messenger ribonucleoprotein 1 protein (FMRP) deficiency leads to fragile X
syndrome (FXS), an autism spectrum disorder. The role of FMRP in prenatal human brain …

Metasurface‐enhanced mid‐infrared spectrochemical imaging of tissues

S Rosas, KA Schoeller, E Chang, H Mei… - Advanced …, 2023 - Wiley Online Library
Label‐free and nondestructive mid‐infrared vibrational hyperspectral imaging is an
essential tissue analysis tool, providing spatially resolved biochemical information critical to …

Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway

Y Guo, M Shen, Q Dong, NM Méndez-Albelo… - Nature …, 2023 - nature.com
Fragile X messenger ribonucleoprotein 1 protein (FMRP) binds many mRNA targets in the
brain. The contribution of these targets to fragile X syndrome (FXS) and related autism …

Gamma oscillation plasticity is mediated via parvalbumin interneurons

MD Hadler, A Tzilivaki, D Schmitz, H Alle… - Science …, 2024 - science.org
Understanding the plasticity of neuronal networks is an emerging field of (patho-)
physiological research, yet the underlying cellular mechanisms remain poorly understood …

circ2CBA: prediction of circRNA-RBP binding sites combining deep learning and attention mechanism

Y Guo, X Lei, L Liu, Y Pan - Frontiers of Computer Science, 2023 - Springer
Abstract Circular RNAs (circRNAs) are RNAs with closed circular structure involved in many
biological processes by key interactions with RNA binding proteins (RBPs). Existing …

Parvalbumin interneuron cell-to-network plasticity: Mechanisms and therapeutic avenues

MD Hadler, H Alle, JRP Geiger - Trends in Pharmacological Sciences, 2024 - cell.com
Alzheimer's disease (AD) and schizophrenia (SCZ) represent two major neuropathological
conditions with a high disease burden. Despite their distinct etiologies, patients suffering …

Genetic influences on the develo** young brain and risk for neuropsychiatric disorders

AM Alex, C Buss, EP Davis, G de Los Campos… - Biological …, 2023 - Elsevier
Imaging genetics provides an opportunity to discern associations between genetic variants
and brain imaging phenotypes. Historically, the field has focused on adults and adolescents; …

Interneuron odyssey: molecular mechanisms of tangential migration

I Toudji, A Toumi, É Chamberland… - Frontiers in Neural …, 2023 - frontiersin.org
Cortical GABAergic interneurons are critical components of neural networks. They provide
local and long-range inhibition and help coordinate network activities involved in various …