Blood eosinophils and chronic obstructive pulmonary disease: a global initiative for chronic obstructive lung disease science committee 2022 review

D Singh, A Agusti, FJ Martinez, A Papi… - American journal of …, 2022 - atsjournals.org
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) published its first report
for the diagnosis and management of chronic obstructive pulmonary disease (COPD) in …

Treatment trials in young patients with chronic obstructive pulmonary disease and pre–chronic obstructive pulmonary disease patients: time to move forward

FJ Martinez, A Agusti, BR Celli, MLK Han… - American journal of …, 2022 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is the end result of a series of dynamic and
cumulative gene–environment interactions over a lifetime. The evolving understanding of …

How inhaled corticosteroids target inflammation in COPD

S Lea, A Higham, A Beech… - European Respiratory …, 2023 - publications.ersnet.org
Inhaled corticosteroids (ICS) are the most commonly used anti-inflammatory drugs for the
treatment of COPD. COPD has been previously described as a “corticosteroid-resistant” …

Targeting type 2 inflammation and epithelial alarmins in chronic obstructive pulmonary disease: a biologics outlook

KF Rabe, S Rennard, FJ Martinez, BR Celli… - American journal of …, 2023 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, progressive
inflammatory airway disease associated with a significant impact on patients' lives, including …

Lung microbiome composition and bronchial epithelial gene expression in patients with COPD versus healthy individuals: a bacterial 16S rRNA gene sequencing and …

MY Ramsheh, K Haldar, A Esteve-Codina… - The Lancet …, 2021 - thelancet.com
Background Chronic obstructive pulmonary disease (COPD) is associated with airway
inflammation and bacterial dysbiosis. The relationship between the airway microbiome and …

Pharmacological treatment of stable chronic obstructive pulmonary disease

D Singh - Respirology, 2021 - Wiley Online Library
Pharmacological treatment for chronic obstructive pulmonary disease (COPD) aims to
alleviate symptoms and reduce the future risk of events such as exacerbations, disease …

Type 2 inflammation in eosinophilic chronic obstructive pulmonary disease

A Higham, A Beech, S Wolosianka, N Jackson… - Allergy, 2020 - pmc.ncbi.nlm.nih.gov
To the Editor, Type 2 (T2) inflammation in asthma encompasses the presence of
eosinophilic inflammation and/or selected cytokines including interleukin (IL)-13. Some …

Blood eosinophil counts and the development of obstructive lung disease: the Kangbuk Samsung Health Study

HY Park, Y Chang, D Kang, YS Hong… - European …, 2021 - publications.ersnet.org
Aim The impact of blood eosinophil counts on the development of chronic obstructive lung
disease (COPD) is unknown. We investigated whether a higher blood eosinophil count was …

IL1RAP expression and the enrichment of IL‐33 activation signatures in severe neutrophilic asthma

YE Badi, B Salcman, A Taylor, B Rana, NZ Kermani… - Allergy, 2023 - Wiley Online Library
Abstract Background Interleukin (IL)‐33 is an upstream regulator of type 2 (T2) eosinophilic
inflammation and has been proposed as a key driver of some asthma phenotypes. Objective …

The association of blood eosinophil counts and FEV1 decline: a cohort study

YS Hong, HY Park, S Ryu, SH Shin… - European …, 2024 - publications.ersnet.org
Background Accelerated lung function decline is characteristic of COPD. However, the
association between blood eosinophil counts and lung function decline, accounting for …