Simple Summary Breast cancer is the most common cancer affecting women under 40 years
of age worldwide, with an increasing number of cases diagnosed each year. Despite this …

Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …

Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost
30% of the population in the UK have a family history of CRC. The quantification of an …

Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

The NCCN Clinical Practice Guidelines in Oncology for Genetic/Familial High-Risk
Assessment: Breast and Ovarian provide recommendations for genetic testing and …

Purpose Testing for germline mutations in BRCA1/2 is standard for select patients with
breast cancer to guide clinical management. Next-generation sequencing (NGS) allows …

BACKGROUND As panel testing becomes more common in clinical practice, it is important
to understand the prevalence and trends associated with the pathogenic variants (PVs) …

ESGE recommends that individuals with hereditary gastrointestinal polyposis syndromes
should be surveilled in dedicated units that provide monitoring of compliance and …

The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant
disorders associated with an increased risk of benign and malignant intestinal and …

This guideline presents recommendations for the management of patients with hereditary
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …