The complement system was defined over a century ago based on its ability to “complement”
the antibody-mediated and cell-mediated immune responses against pathogens. Today our …

As the largest endocrine organ, adipose tissue secretes many bioactive molecules that
circulate in blood, collectively termed adipokines. Efforts to identify such metabolic …

Aims/hypothesis Oxidative stress, inflammation and cell death are closely involved in the
development of diabetic cardiomyopathy (DCM). C1q/tumour necrosis factor-related protein …

The complement system is an evolutionary old and crucial component of innate immunity,
which is key to the detection and removal of invading pathogens. It was initially discovered …

The last 15 years have seen an explosion of new findings on the role of complement, a
major arm of the immune system, in the central nervous system (CNS) compartment …

C1q/tumor necrosis factor-related protein-3 (CTRP3) had shown its angiogenesis and
enhancement of mitochondrial biogenesis properties in the treatment of myocardial …

Aims: Vascular calcification is associated with cardiovascular death in patients with chronic
kidney disease (CKD). Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) …

Background Mitochondrial biogenesis is crucial for the maintenance of mitochondrial
function and cellular homeostasis. C1q/tumor necrosis factor-related protein-3 (CTRP3) is …

The complement system, well known for its central role in innate immunity, is currently
emerging as an unexpected, cell‐autonomous, orchestrator of normal cell physiology …

Prolonged exposure of the peritoneum to high glucose dialysate leads to the development of
peritoneal fibrosis (PF), and apoptosis of peritoneal mesothelial cells (PMCs) is a major …