The role of the microtubule cytoskeleton in neurodevelopmental disorders
M Lasser, J Tiber, LA Lowery - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Neurons depend on the highly dynamic microtubule (MT) cytoskeleton for many different
processes during early embryonic development including cell division and migration …
processes during early embryonic development including cell division and migration …
Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes
TJ Edwards, EH Sherr, AJ Barkovich, LJ Richards - Brain, 2014 - academic.oup.com
The corpus callosum is the largest fibre tract in the brain, connecting the two cerebral
hemispheres, and thereby facilitating the integration of motor and sensory information from …
hemispheres, and thereby facilitating the integration of motor and sensory information from …
The growth cone cytoskeleton in axon outgrowth and guidance
Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …
ReMAP** the microtubule landscape: How phosphorylation dictates the activities of microtubule‐associated proteins
A Ramkumar, BY Jong… - Developmental …, 2018 - Wiley Online Library
Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …
co‐purification with microtubules assembled from mammalian brain lysate. They have since …
Guiding neuronal cell migrations
Neuronal migration is, along with axon guidance, one of the fundamental mechanisms
underlying the wiring of the brain. As other organs, the nervous system has acquired the …
underlying the wiring of the brain. As other organs, the nervous system has acquired the …
[HTML][HTML] Trekking across the brain: the journey of neuronal migration
R Ayala, T Shu, LH Tsai - Cell, 2007 - cell.com
The correct positioning of neurons during development—achieved through directed
migration—is the basis for proper brain function. Several decades of research have yielded …
migration—is the basis for proper brain function. Several decades of research have yielded …
Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms
PAC 't Hoen, Y Ariyurek, HH Thygesen… - Nucleic acids …, 2008 - academic.oup.com
The hippocampal expression profiles of wild-type mice and mice transgenic for δC-
doublecortin-like kinase were compared with Solexa/Illumina deep sequencing technology …
doublecortin-like kinase were compared with Solexa/Illumina deep sequencing technology …
From genes to behavior in developmental dyslexia
All four genes thus far linked to developmental dyslexia participate in brain development,
and abnormalities in brain development are increasingly reported in dyslexia. Comparable …
and abnormalities in brain development are increasingly reported in dyslexia. Comparable …
Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation
T Plümpe, D Ehninger, B Steiner, F Klempin… - BMC neuroscience, 2006 - Springer
Background In the course of adult hippocampal neurogenesis most regulation takes place
during the phase of doublecortin (DCX) expression, either as pro-proliferative effect on …
during the phase of doublecortin (DCX) expression, either as pro-proliferative effect on …
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
The polarization of axon and dendrites underlies the ability of neurons to integrate and
transmit information in the brain. We show here that the serine/threonine kinase LKB1 …
transmit information in the brain. We show here that the serine/threonine kinase LKB1 …