The role of the microtubule cytoskeleton in neurodevelopmental disorders

M Lasser, J Tiber, LA Lowery - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Neurons depend on the highly dynamic microtubule (MT) cytoskeleton for many different
processes during early embryonic development including cell division and migration …

Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes

TJ Edwards, EH Sherr, AJ Barkovich, LJ Richards - Brain, 2014 - academic.oup.com
The corpus callosum is the largest fibre tract in the brain, connecting the two cerebral
hemispheres, and thereby facilitating the integration of motor and sensory information from …

The growth cone cytoskeleton in axon outgrowth and guidance

EW Dent, SL Gupton, FB Gertler - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

ReMAP** the microtubule landscape: How phosphorylation dictates the activities of microtubule‐associated proteins

A Ramkumar, BY Jong… - Developmental …, 2018 - Wiley Online Library
Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …

Guiding neuronal cell migrations

O Marín, M Valiente, X Ge… - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
Neuronal migration is, along with axon guidance, one of the fundamental mechanisms
underlying the wiring of the brain. As other organs, the nervous system has acquired the …

[HTML][HTML] Trekking across the brain: the journey of neuronal migration

R Ayala, T Shu, LH Tsai - Cell, 2007 - cell.com
The correct positioning of neurons during development—achieved through directed
migration—is the basis for proper brain function. Several decades of research have yielded …

Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms

PAC 't Hoen, Y Ariyurek, HH Thygesen… - Nucleic acids …, 2008 - academic.oup.com
The hippocampal expression profiles of wild-type mice and mice transgenic for δC-
doublecortin-like kinase were compared with Solexa/Illumina deep sequencing technology …

From genes to behavior in developmental dyslexia

AM Galaburda, J LoTurco, F Ramus, RH Fitch… - Nature …, 2006 - nature.com
All four genes thus far linked to developmental dyslexia participate in brain development,
and abnormalities in brain development are increasingly reported in dyslexia. Comparable …

Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation

T Plümpe, D Ehninger, B Steiner, F Klempin… - BMC neuroscience, 2006 - Springer
Background In the course of adult hippocampal neurogenesis most regulation takes place
during the phase of doublecortin (DCX) expression, either as pro-proliferative effect on …

LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons

AP Barnes, BN Lilley, YA Pan, LJ Plummer, AW Powell… - Cell, 2007 - cell.com
The polarization of axon and dendrites underlies the ability of neurons to integrate and
transmit information in the brain. We show here that the serine/threonine kinase LKB1 …