Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …

In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of
oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological …

Type 2 diabetes (T2D) is a highly prevalent and chronic metabolic disorder. Recent
evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) …

N-acetylcysteine (NAC), an acetylated derivative of the amino acid L-cysteine, has been
widely used as a mucolytic agent and antidote for acetaminophen overdose since the 1960s …

Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of
toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and …

Aims/hypothesis Islet amyloid in type 2 diabetes contributes to loss of beta cell mass and
function. Since islets are susceptible to oxidative stress-induced toxicity, we sought to …

Diabetes affects hundreds of millions of patients worldwide. Despite the advances in
understanding the disease and therapeutic options, it remains a leading cause of death and …

Human amylin is a small fibrillogenic protein that is the major constituent of pancreatic islet
amyloid, which occurs in most subjects with type 2 diabetes. There is evidence that it can …

Thiols are the organic compounds that contain a sulphydryl group. Among all the
antioxidants that are available in the body, thiols constitute the major portion of the total body …

Type 2 diabetes (T2D) is characterized by chronic hyperglycemia secondary to the decline
of functional beta-cells and is usually accompanied by a reduced sensitivity to insulin …