Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Gaps remain in our understanding of the precise molecular mechanisms by which insulin
regulates glucose uptake in fat and muscle cells. Recent evidence suggests that insulin …

Little is known about how nerve growth factor (NGF) signaling controls the regulated
assembly of microtubules that underlies axon growth. Here we demonstrate that a tightly …

To enhance glucose uptake into muscle and fat cells, insulin stimulates the translocation of
GLUT4 glucose transporters from intracellular membranes to the cell surface. This response …

Insulin controls glucose flux into muscle and fat by regulating the trafficking of GLUT4
between the interior and surface of cells. Here, we show that the AS160 Rab GTPase …

Glucose entry into muscle cells is precisely regulated by insulin, through recruitment of
GLUT4 (glucose transporter-4) to the membrane of muscle and fat cells. Work done over …

Skeletal muscle is a major glucose‐utilizing tissue in the absorptive state and the major
glucose transporter expressed in muscle in adulthood is GLUT4. GLUT4 expression is …

Glucose transport into muscle is the initial process in glucose clearance and is uniformly
defective in insulin-resistant conditions of obesity, metabolic syndrome, and Type II diabetes …

Insulin and insulin-like growth factor (IGF) receptors utilize common phosphoinositide 3-
kinase/Akt and Ras/extracellular signal-regulated kinase signaling pathways to mediate a …

Axon growth is a highly regulated process that requires stimulating signals from extracellular
factors. The extracellular signals are then transduced to regulate coordinately gene …