Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …

Cannabaceae plants Cannabis sativa L. and Humulus lupulus L. are rich in terpenes–both
are typically comprised of terpenes as up to 3–5% of the dry-mass of the female …

Background Medicinal cannabis registries typically report pain as the most common reason
for use. It would be clinically useful to identify patterns of cannabis treatment in migraine and …

The type 2 cannabinoid receptor (CB2R) was initially regarded as a peripheral cannabinoid
receptor. However, recent technological advances in gene detection, alongside the …

Cannabis, renowned for its historical medicinal use, harbours various bioactive compounds—
cannabinoids, terpenes, and flavonoids. While major cannabinoids like delta-9 …

Psychiatric disorders are frequently encountered in many neurological disorders, such as
Alzheimer's and Parkinson diseases along with epilepsy, migraine, essential tremors, and …

Despite low levels of cannabinoid receptor type 2 (CB2R) expression in the central nervous
system in human and rodents, a growing body of evidence shows CB2R involvement in …

The cannabinoid type two receptors (CB2), an important component of the endocannabinoid
system, have recently emerged as neuromodulators and therapeutic targets for …

Background: β-Caryophyllene (BCP) is a natural bicyclic sesquiterpene abundantly found in
essential oils from various spices, fruits and medicinal as well as ornamental plants. It is …

Parkinson disease (PD) is a neurodegenerative disease characterized by progressive
dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) area. The …