Computational model of calcium dynamics-dependent dopamine regulation and dysregulation in a dopaminergic neuron cell

A Pawar, KR Pardasani - The European Physical Journal Plus, 2023 - Springer
Abstract Calcium (Ca2+) signaling is essential for regulating dopamine (DA) concentration
levels in neurons. The alterations in the different mechanisms of [Ca2+] dynamics can cause …

Simulation of biochemical dynamics of and in fibroblast cell

A Kothiya, N Adlakha - Journal of Bioenergetics and Biomembranes, 2023 - Springer
Calcium dynamics is not only responsible for maintaining the framework and functions of the
cell but also plays a role in the dynamics of other biochemical systems in the cell …

Cellular nitric oxide synthesis is affected by disorders in the interdependent and dynamics during cystic fibrosis disease

AB Kothiya, N Adlakha - Journal of Biological Physics, 2023 - Springer
Abstract Calcium (C a 2+), inositol trisphosphate (IP 3), and nitric oxide (NO) signaling are
essential to maintain the structural integrity and physiological activity of fibroblast cells. The …

Spatio temporal interdependent calcium and buffer dynamics regulating DAG in a hepatocyte cell due to obesity

V Mishra, N Adlakha - Journal of Bioenergetics and Biomembranes, 2023 - Springer
Abstract Calcium ions (Ca2+) serve as a crucial signaling mechanism in almost all cells. The
buffers are proteins that bind free Ca2+ to reduce the cell's Ca2+ concentration. The most …

Fractional-order reaction–diffusion model to study the dysregulatory impacts of superdiffusion and memory on neuronal calcium and IP3 dynamics

A Pawar, KR Pardasani - The European Physical Journal Plus, 2023 - Springer
The models for the dynamics of single systems like calcium ([Ca 2+]) in a neuron cell are
able to provide information about factors affecting the calcium regulation in the neuron cell …

Numerical model of hepatic glycogen phosphorylase regulation by nonlinear interdependent dynamics of calcium and

Y Jagtap, N Adlakha - The European Physical Journal Plus, 2023 - Springer
The liver's primary function is to integrate various signals to retain stable blood glucose
levels. Glycogenolysis, gluconeogenesis, and other metabolic processes are regulated by …

Radial Basis Function-Based Differential Quadrature Approach to Study Reaction–Diffusion of Ca2+ in T Lymphocyte

H Bhardwaj, N Adlakha - International Journal of Computational …, 2023 - World Scientific
T lymphocytes have a primary role in both health and disease. Extracellular and intracellular
signals determine whether a T-cell activates different cells, divides, or begins apoptosis. The …

Numerical simulation of calcium dynamics dependent ATP degradation, IP3 and NADH production due to obesity in a hepatocyte cell

V Mishra, N Adlakha - Journal of Biological Physics, 2023 - Springer
Abstract Calcium (Ca 2+) signals have a crucial role in regulating various processes of
almost every cell to maintain its structure and function. Calcium dynamics has been studied …

Numerical investigations and simulation of calcium distribution in the alpha-cell

T Singh, N Adlakha - Bulletin of Biomathematics, 2023 - bulletinbiomath.org
The α-cells are a part of islets of Langerhans located in the pancreas and are responsible for
glucagon secretion. Calcium signaling is crucial for the regulation of the functions and …

2D dynamic analysis of the disturbances in the calcium neuronal model and its implications in neurodegenerative disease

H Joshi, BK Jha - Cognitive Neurodynamics, 2023 - Springer
Ca2+ signaling is an essential function of neurons to control synaptic activity, memory
formation, fertilization, proliferation, etc. Protein and voltage-dependent calcium channels …