Understudied proteins: opportunities and challenges for functional proteomics

G Kustatscher, T Collins, AC Gingras, T Guo… - Nature …, 2022 - nature.com
Most research aiming at understanding the molecular foundations of life and disease has
focused on a limited set of increasingly well-known proteins while the biological functions of …

Emerging applications of metabolomics in drug discovery and precision medicine

DS Wishart - Nature reviews Drug discovery, 2016 - nature.com
Metabolomics is an emerging'omics' science involving the comprehensive characterization
of metabolites and metabolism in biological systems. Recent advances in metabolomics …

Reptile Search Algorithm (RSA): A nature-inspired meta-heuristic optimizer

L Abualigah, M Abd Elaziz, P Sumari, ZW Geem… - Expert Systems with …, 2022 - Elsevier
This paper proposes a novel nature-inspired meta-heuristic optimizer, called Reptile Search
Algorithm (RSA), motivated by the hunting behaviour of Crocodiles. Two main steps of …

Pinpointing secondary metabolites that shape the composition and function of the plant microbiome

RP Jacoby, A Koprivova… - Journal of Experimental …, 2021 - academic.oup.com
One of the major questions in contemporary plant science involves determining the
functional mechanisms that plants use to shape their microbiome. Plants produce a plethora …

The potential of endurance exercise-derived exosomes to treat metabolic diseases

A Safdar, A Saleem, MA Tarnopolsky - Nature Reviews Endocrinology, 2016 - nature.com
Endurance exercise-mediated multisystemic adaptations are known to mitigate metabolism-
related disorders such as obesity and type 2 diabetes mellitus (T2DM). However, the …

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

WB Dunn, D Broadhurst, P Begley, E Zelena… - Nature protocols, 2011 - nature.com
Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

M Jain, R Nilsson, S Sharma, N Madhusudhan… - Science, 2012 - science.org
Metabolic reprogramming has been proposed to be a hallmark of cancer, yet a systematic
characterization of the metabolic pathways active in transformed cells is currently lacking …

Metabolite profiles and the risk of develo** diabetes

TJ Wang, MG Larson, RS Vasan, S Cheng, EP Rhee… - Nature medicine, 2011 - nature.com
Emerging technologies allow the high-throughput profiling of metabolic status from a blood
specimen (metabolomics). We investigated whether metabolite profiles could predict the …

Metabolite profiling identifies pathways associated with metabolic risk in humans

S Cheng, EP Rhee, MG Larson, GD Lewis… - Circulation, 2012 - Am Heart Assoc
Background—Although metabolic risk factors are known to cluster in individuals who are
prone to develo** diabetes mellitus and cardiovascular disease, the underlying biological …

Mass spectrometry‐based metabolomics

K Dettmer, PA Aronov… - Mass spectrometry …, 2007 - Wiley Online Library
This review presents an overview of the dynamically develo** field of mass spectrometry‐
based metabolomics. Metabolomics aims at the comprehensive and quantitative analysis of …