Understudied proteins: opportunities and challenges for functional proteomics
Most research aiming at understanding the molecular foundations of life and disease has
focused on a limited set of increasingly well-known proteins while the biological functions of …
focused on a limited set of increasingly well-known proteins while the biological functions of …
Emerging applications of metabolomics in drug discovery and precision medicine
DS Wishart - Nature reviews Drug discovery, 2016 - nature.com
Metabolomics is an emerging'omics' science involving the comprehensive characterization
of metabolites and metabolism in biological systems. Recent advances in metabolomics …
of metabolites and metabolism in biological systems. Recent advances in metabolomics …
Reptile Search Algorithm (RSA): A nature-inspired meta-heuristic optimizer
This paper proposes a novel nature-inspired meta-heuristic optimizer, called Reptile Search
Algorithm (RSA), motivated by the hunting behaviour of Crocodiles. Two main steps of …
Algorithm (RSA), motivated by the hunting behaviour of Crocodiles. Two main steps of …
Pinpointing secondary metabolites that shape the composition and function of the plant microbiome
RP Jacoby, A Koprivova… - Journal of Experimental …, 2021 - academic.oup.com
One of the major questions in contemporary plant science involves determining the
functional mechanisms that plants use to shape their microbiome. Plants produce a plethora …
functional mechanisms that plants use to shape their microbiome. Plants produce a plethora …
The potential of endurance exercise-derived exosomes to treat metabolic diseases
Endurance exercise-mediated multisystemic adaptations are known to mitigate metabolism-
related disorders such as obesity and type 2 diabetes mellitus (T2DM). However, the …
related disorders such as obesity and type 2 diabetes mellitus (T2DM). However, the …
Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry
Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
Metabolic reprogramming has been proposed to be a hallmark of cancer, yet a systematic
characterization of the metabolic pathways active in transformed cells is currently lacking …
characterization of the metabolic pathways active in transformed cells is currently lacking …
Metabolite profiles and the risk of develo** diabetes
Emerging technologies allow the high-throughput profiling of metabolic status from a blood
specimen (metabolomics). We investigated whether metabolite profiles could predict the …
specimen (metabolomics). We investigated whether metabolite profiles could predict the …
Metabolite profiling identifies pathways associated with metabolic risk in humans
Background—Although metabolic risk factors are known to cluster in individuals who are
prone to develo** diabetes mellitus and cardiovascular disease, the underlying biological …
prone to develo** diabetes mellitus and cardiovascular disease, the underlying biological …
Mass spectrometry‐based metabolomics
This review presents an overview of the dynamically develo** field of mass spectrometry‐
based metabolomics. Metabolomics aims at the comprehensive and quantitative analysis of …
based metabolomics. Metabolomics aims at the comprehensive and quantitative analysis of …