Lipoprotein (a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement

F Kronenberg, S Mora, ESG Stroes… - European heart …, 2022 - academic.oup.com
Abstract This 2022 European Atherosclerosis Society lipoprotein (a)[Lp (a)] consensus
statement updates evidence for the role of Lp (a) in atherosclerotic cardiovascular disease …

Interleukin-6: designing specific therapeutics for a complex cytokine

C Garbers, S Heink, T Korn, S Rose-John - Nature reviews Drug …, 2018 - nature.com
Abstract Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological
functions that include regulation of immune cell proliferation and differentiation …

IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial

PM Ridker, M Devalaraja, FMM Baeres… - The Lancet, 2021 - thelancet.com
Background IL-6 has emerged as a pivotal factor in atherothrombosis. Yet, the safety and
efficacy of IL-6 inhibition among individuals at high atherosclerotic risk but without a …

Statin therapy increases lipoprotein (a) levels

S Tsimikas, PLSM Gordts, C Nora, C Yeang… - European heart …, 2020 - academic.oup.com
Abstract Aims Lipoprotein (a)[Lp (a)] is elevated in 20–30% of people. This study aimed to
assess the effect of statins on Lp (a) levels. Methods and results This subject-level meta …

Targeting innate immunity-driven inflammation in CKD and cardiovascular disease

T Speer, S Dimmeler, SJ Schunk, D Fliser… - Nature Reviews …, 2022 - nature.com
Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

[HTML][HTML] Obese individuals with and without type 2 diabetes show different gut microbial functional capacity and composition

LB Thingholm, MC Rühlemann, M Koch, B Fuqua… - Cell host & …, 2019 - cell.com
Obesity and type 2 diabetes (T2D) are metabolic disorders that are linked to microbiome
alterations. However, their co-occurrence poses challenges in disentangling microbial …

Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

J Wang, LB Thingholm, J Skiecevičienė, P Rausch… - Nature …, 2016 - nature.com
Human gut microbiota is an important determinant for health and disease, and recent
studies emphasize the numerous factors sha** its diversity. Here we performed a genome …

Oxidized phospholipids as a unifying theory for lipoprotein (a) and cardiovascular disease

MB Boffa, ML Koschinsky - Nature Reviews Cardiology, 2019 - nature.com
Epidemiological and clinical studies over the past decade have firmly established that
elevated plasma concentrations of lipoprotein (a)(Lp (a)) are an important, independent and …

[HTML][HTML] Host-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy

R Pryor, P Norvaisas, G Marinos, L Best, LB Thingholm… - Cell, 2019 - cell.com
Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging
drug. We set out to address the fundamental question of how gut microbes and nutrition, key …