Challenges of reducing protein-bound uremic toxin levels in chronic kidney disease and end stage renal disease
The prevalence of chronic kidney disease (CKD) in the worldwide population is currently
estimated between 11% and 13%. Adequate renal clearance is compromised in these …
estimated between 11% and 13%. Adequate renal clearance is compromised in these …
Adsorption-and displacement-based approaches for the removal of protein-bound uremic toxins
End-stage renal disease (ESRD) patients rely on renal replacement therapies to survive.
Hemodialysis (HD), the most widely applied treatment, is responsible for the removal of …
Hemodialysis (HD), the most widely applied treatment, is responsible for the removal of …
Removal of protein-bound uremic toxins during hemodialysis using a binding competitor
Results We studied 18 patients on maintenance hemodialysis: age 36±11 years old, ten
women, and mean vintage of 37±37 months. Compared with during the preinfusion period …
women, and mean vintage of 37±37 months. Compared with during the preinfusion period …
Self-assembled membrane composed of amyloid-like proteins for efficient size-selective molecular separation and dialysis
F Yang, F Tao, C Li, L Gao, P Yang - Nature communications, 2018 - nature.com
The design and scalable construction of robust ultrathin protein membranes with tunable
separation properties remain a key challenge in chemistry and materials science. Here, we …
separation properties remain a key challenge in chemistry and materials science. Here, we …
Improved dialytic removal of protein-bound uraemic toxins with use of albumin binding competitors: an in vitro human whole blood study
Protein-bound uraemic toxins (PBUTs) cause various deleterious effects in end-stage kidney
disease patients, because their removal by conventional haemodialysis (HD) is severely …
disease patients, because their removal by conventional haemodialysis (HD) is severely …
Removal of protein-bound uremic toxins using binding competitors in hemodialysis: a narrative review
Removal of protein-bound uremic toxins (PBUTs) during conventional dialysis is insufficient.
PBUTs are associated with comorbidities and mortality in dialysis patients. Albumin is the …
PBUTs are associated with comorbidities and mortality in dialysis patients. Albumin is the …
Using binding competitors of albumin to promote the removal of protein-bound uremic toxins in hemodialysis: hope or pipe dream?
Chronic kidney disease is associated with the accumulation of a large range of uremic
retention solutes as referred to as uremic toxins. Some of these compounds belong to the …
retention solutes as referred to as uremic toxins. Some of these compounds belong to the …
Improved dialysis removal of protein-bound uremic toxins by salvianolic acids
J Li, Y Wang, X Xu, W Cao, Z Shen, N Wang, J Leng… - Phytomedicine, 2019 - Elsevier
Background Indoxyl sulfate (IS) and p-cresyl sulfate (pCS) are two key protein-bound uremic
toxins that accumulate in patients with end-stage renal disease. IS and pCS cannot be …
toxins that accumulate in patients with end-stage renal disease. IS and pCS cannot be …
Gut-derived uremic toxins in CKD: an Improved Approach for the evaluation of serum indoxyl sulfate in clinical practice
G Caggiano, L Amodio, A Stasi, NA Colabufo… - International Journal of …, 2023 - mdpi.com
In the past years, indoxyl sulfate has been strongly implicated in kidney disease progression
and contributed to cardiovascular morbidity. Moreover, as a result of its elevated albumin …
and contributed to cardiovascular morbidity. Moreover, as a result of its elevated albumin …
Multi-sites polycyclodextrin adsorbents for removal of protein-bound uremic toxins combining with hemodialysis
J Li, L Han, J **e, S Liu, L Jia - Carbohydrate polymers, 2020 - Elsevier
Accumulation of protein-bound uremic toxins (PBUTs) has a high incidence in the blood of
hemodialysis-treated patients with chronic kidney disease. Development of adsorbent for the …
hemodialysis-treated patients with chronic kidney disease. Development of adsorbent for the …