VEGFR, a receptor tyrosine kinase inhibitor (TKI), is an important regulatory factor that
promotes angiogenesis and vascular permeability. It plays a significant role in processes …

Introduction The success of the CDK4/6 inhibitor Ibrance™(Palbociclib) as an anticancer
agent inspired and directed more efforts toward the discovery of selective cyclin-dependent …

Several studies have indicated the potential therapeutic outcomes of combining selective
COX-2 inhibitors with tubulin-targeting anticancer agents. In the current study, a novel series …

Abstract A new series of 2-(4-(2-oxo-1, 2-dihydroquinolin-4-yl) piperazin-1-yl)-N-(4-
phenylthiazol-2-yl) acetamide derivatives were synthesized and evaluated for anticancer …

Many medicinal plants have been utilized for centuries despite the lack of scientific evidence
of their therapeutic effects. This study evaluated the phytochemical and dual biological …

Targeting P-glycoprotein (P-gp, ABCB1 transporter), which plays an essential role in multi-
drug resistance (MDR) in cancers, with new cytotoxic agents is a promising strategy in …

Cancer is the second leading cause of death worldwide, following cardiovascular disease. 1
This complicated illness can result from a variety of spatiotemporal alterations in cellular …

A series of new fluorene-heterocyclic sulfonamide conjugates were designed and
synthesized as potential anticancer agents. In the design of the conjugates, heterocyclic ring …

Breast cancer is a complex and multi-drug resistant (MDR) disease, which could result in the
failure of many chemotherapeutic clinical agents. Discovering effective molecules from …

Acanthospermum hispidum DC. is a plant with extensive traditional use in folk medicine for
treatment of various infections in Sudan including jaundice, stomach discomfort …