Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan
The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …
disease caused by tobacco smoking in genetically susceptible individuals has been …
Update on the pathogenesis of chronic obstructive pulmonary disease
Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on …
Background Idiopathic pulmonary fibrosis (IPF) is an age-related, chronic, irreversible
fibrotic lung disease. IPF is associated with increased senescent cells burden, which may be …
fibrotic lung disease. IPF is associated with increased senescent cells burden, which may be …
Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study
Background Cellular senescence is a key mechanism that drives age-related diseases, but
has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a …
has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a …
Cellular senescence mediates fibrotic pulmonary disease
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling,
leading to compromised lung function. Cellular senescence markers are detectable within …
leading to compromised lung function. Cellular senescence markers are detectable within …
[HTML][HTML] Inflammation and immunity in IPF pathogenesis and treatment
P Heukels, CC Moor, JH Von der Thüsen… - Respiratory …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive, and ultimately fatal, chronic interstitial
lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar …
lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar …
Syndrome of combined pulmonary fibrosis and emphysema: an official ATS/ERS/JRS/ALAT research statement
Background: The presence of emphysema is relatively common in patients with fibrotic
interstitial lung disease. This has been designated combined pulmonary fibrosis and …
interstitial lung disease. This has been designated combined pulmonary fibrosis and …
[HTML][HTML] Oxidative stress and pulmonary fibrosis
P Cheresh, SJ Kim, S Tulasiram, DW Kamp - Biochimica et Biophysica Acta …, 2013 - Elsevier
Oxidative stress is implicated as an important molecular mechanism underlying fibrosis in a
variety of organs, including the lungs. However, the causal role of reactive oxygen species …
variety of organs, including the lungs. However, the causal role of reactive oxygen species …
New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis is a serious and progressive chronic lung disease that is
characterised by altered cellular composition and homoeostasis in the peripheral lung …
characterised by altered cellular composition and homoeostasis in the peripheral lung …
The role of epithelial damage in the pulmonary immune response
Pulmonary epithelial cells are widely considered to be the first line of defence in the lung
and are responsible for coordinating the innate immune response to injury and subsequent …
and are responsible for coordinating the innate immune response to injury and subsequent …