Despite the intense scientific efforts made, there are still many tumors that are difficult to treat
and the percentage of patient survival in the long-term is still too low. Thus, new approaches …

Plant natural products including alkaloids, polyphenols, terpenoids and flavonoids have
been reported to exert anticancer activity by targeting various metabolic pathways. The …

Background: There is evidence that high level of serum lactate dehydrogenase (LDH) is
associated with poorer overall survival in several malignancies, but its link to cancer-specific …

Abnormal lipid metabolism is a hallmark of tumorigenesis. Accumulating evidence
demonstrates that fatty acid synthase (FAS, FASN) is a metabolic oncogene that supports …

Increasing evidence confirmed that the Warburg effect plays an important role involved in
the progression of malignant tumors. Resibufogenin (RES) has been proved to have a …

Cancer cells can use a variety of metabolic substrates to fulfill the bioenergetic and
biosynthetic needs of their oncogenic program. Besides bioenergetics, cancer cell …

Increased glucose uptake mediated by glucose transporters and reliance on glycolysis are
common features of malignant cells. Hypoxia-inducible factor-1α supports the adaptation of …

Alpha-fetoprotein (AFP) is a cancer biomarker that aids in early detection, prognosis
prediction, and recurrence monitoring of liver cancer. In this study, a graphene-metal …

Background Clinical parameters and proteins have recently been suggested as possible
causes of radiotherapy (RT) resistance in cervical carcinoma (CC). The objective of the …

Emerging evidence has shown that endoplasmic reticulum (ER) stress promotes sorafenib
resistance in hepatocellular carcinoma (HCC). However, the underlying mechanisms are …