Simple Summary This review provides an in depth analysis of the role of bromodomain-
containing proteins in cancer development. As readers of acetylated lysine on nucleosomal …

E3 ubiquitin ligases determine the substrate specificity and catalyze the ubiquitination of
lysine residues. HUWE1 is a catalytic HECT domain-containing giant E3 ligase that contains …

Simple Summary BRPF1 (also named as BR140) was identified 28 years ago, and it was not
until the past 5 years that its mutations in humans caught increasing attention. Those …

The histone acetyltransferase HBO1, also known as KAT7, is a major chromatin modifying
enzyme responsible for H3 and H4 acetylation. It is found within two distinct tetrameric …

Epigenetic mechanisms involving DNA methylation and chromatin modifications have
emerged as critical facilitators of cancer heterogeneity, substantially affecting cancer …

Ubiquitination-mediated proteolysis or regulation of proteins, ultimately executed by E3
ubiquitin ligases, control a wide array of cellular processes, including transcription, cell …

Chicken body weight (BW) is a critical trait in breeding. Although genetic variants associated
with BW have been investigated by genome-wide association studies (GWAS), the …

Abstract Background Lysine acetyltransferase 6B (KAT6B) encodes a highly conserved
histone acetyltransferase that regulates the expression of multiple genes and is essential for …

Many essential biological processes are regulated through protein–protein interactions.
Some natural and synthetic small‐molecule compounds also operate through induced …

The E3 ubiquitin ligase HUWE1 (HECT, UBA And WWE Domain Containing E3 Ubiquitin
Protein Ligase 1) regulates neural stem cells'(NSCs) differentiation during neurogenesis in …