Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

Eukaryotic cilia and flagella, including primary cilia and sensory cilia, are highly conserved
organelles that project from the surfaces of many cells. The assembly and maintenance of …

The green alga Chlamydomonas reinhardtii is a leading unicellular model for dissecting
biological processes in photosynthetic eukaryotes. However, its usefulness has been limited …

Life implies movement. Most forms of movement in the living world are powered by tiny
protein machines known as molecular motors. Among the best known are motors that use …

C. elegans has a highly developed chemosensory system that enables it to detect a wide
variety of volatile (olfactory) and water-soluble (gustatory) cues associated with food …

Recent evidence has suggested an association between structural and/or functional defects
in the primary apical cilium of vertebrate epithelia and polycystic kidney disease (PKD). In …

Cilia, as motile and sensory organelles, have been implicated in normal development, as
well as diseases including cystic kidney disease, hydrocephalus and situs inversus. In …

Many organs are composed of epithelial tubes that transport vital fluids. Such tubular organs
develop in many different ways and generate tubes of widely varying sizes and structures …

Polycystic kidney disease (PKD), a common genetic cause of chronic renal failure in
children and adults, is characterized by the accumulation of fluid-filled cysts in the kidney …

Cilia and flagella have attracted tremendous attention in recent years as research
demonstrated crucial roles for these organelles in coordinating a number of physiologically …