Intron retention has long been an exemplar of regulated splicing with case studies of
individual events serving as models that provided key mechanistic insights into the process …

Intron retention (IR) is a form of alternative splicing that has long been neglected in
mammalian systems although it has been studied for decades in non-mammalian species …

Synapses are crucial structures that mediate signal transmission between neurons in
complex neural circuits and display considerable morphological and electrophysiological …

Intron retention (IR) is widely recognized as a consequence of mis-splicing that leads to
failed excision of intronic sequences from pre-messenger RNAs. Our bioinformatic analyses …

Alternative splicing modulates expression of most human genes. The kinetic model of
cotranscriptional splicing suggests that slow elongation expands and that fast elongation …

Differentiated cells acquire unique structural and functional traits through coordinated
expression of lineage-specific genes. An extensive battery of genes encoding components …

The explosion in sequencing technologies has provided us with an instrument to describe
mammalian transcriptomes at unprecedented depths. This has revealed that alternative …

Until recently, retention of introns in mature mRNAs has been regarded as a consequence of
mis‐splicing. Intron‐retaining transcripts are thought to be non‐functional because they are …

DHA (docosahexaenoic acid) is perhaps the most pleiotropic molecule in nerve cell biology.
This long-chain highly unsaturated fatty acid has evolved to accomplish essential functions …

Alternative splicing is a process to differentially link exon regions in a single precursor
mRNA to produce two or more different mature mRNAs, a strategy frequently used by higher …