[HTML][HTML] Current status and advances to improving drug delivery in diffuse intrinsic pontine glioma

LM Arms, RJ Duchatel, ER Jackson… - Journal of Controlled …, 2024 - Elsevier
Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic
pontine glioma-DIPG), is the primary cause of brain tumor-related death in pediatric patients …

Tumor and immune cell types interact to produce heterogeneous phenotypes of pediatric high-grade glioma

J DeSisto, AM Donson, AM Griesinger, R Fu… - Neuro …, 2024 - academic.oup.com
Background Pediatric high-grade gliomas (PHGG) are aggressive brain tumors with 5-year
survival rates ranging from< 2% to 20% depending upon subtype. PHGG presents differently …

Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas

G Pericoli, A Galardi, A Paolini, LL Petrilli, G Pepe… - Cell & Bioscience, 2023 - Springer
Abstract Background Paediatric-type diffuse High-Grade Gliomas (PDHGG) are highly
heterogeneous tumours which include distinct cell sub-populations co-existing within the …

Applications and current challenges of chimeric antigen receptor T cells in treating high-grade gliomas in adult and pediatric populations

N Jovanovich, A Habib, NUF Hameed, L Edwards… - …, 2023 - Taylor & Francis
High-grade gliomas (HGGs) continue to be some of the most devastating diseases in the
USA. Despite extensive efforts, the survival of HGG patients has remained relatively …

Glial fibrillary acidic protein, neurofilament light, matrix metalloprotease 3 and fatty acid binding protein 4 as non-invasive brain tumor biomarkers

A Ghorbani, MK Chatanaka, LM Avery, M Wang… - Clinical Proteomics, 2024 - Springer
Background Gliomas are aggressive malignant tumors, with poor prognosis. There is an
unmet need for the discovery of new, non-invasive biomarkers for differential diagnosis …

[HTML][HTML] Targeting Glioblastoma: Advances in Precision Drug Delivery

AT Rajendran… - Journal of Young …, 2024 - jyoungpharm.org
Glioblastoma Multiforme (GBM) is still one of the most aggressive and resistant brain
tumours, and current treatment options provide only minimal improvements in survival …

Investigation of Heterogeneity and Stemlike Cell Drivers of Oncogenesis in Pediatric High Grade Glioma

J DeSisto - 2023 - search.proquest.com
Pediatric high-grade gliomas (PHGG) are aggressive CNS tumors with five-year survival
rates of 2% to 20% depending upon subtype. Consistently effective drug therapies have not …

Molecular Determinants of Diffuse Midline Glioma of the Pons Vulnerability to the Histone Deacetylase Inhibitor, Quisinostat

D Paine - 2023 - search.proquest.com
Abstract Diffuse Midline Glioma of the Pons (DMG/Pons) represents a highly aggressive
pediatric high-grade glioma, standing as a predominant cause of brain tumor-related …