Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies

D Seo, DM Holtzman - Experimental & molecular medicine, 2024 - nature.com
Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease. Despite
tremendous research efforts to understand this complex disease, the exact pathophysiology …

[HTML][HTML] Long COVID or post-acute sequelae of COVID-19 (PASC): an overview of biological factors that may contribute to persistent symptoms

AD Proal, MB VanElzakker - Frontiers in microbiology, 2021 - frontiersin.org
The novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused
a pandemic of coronavirus disease 2019 (COVID-19). Across the globe, a subset of patients …

Pathogenesis and virulence of herpes simplex virus

S Zhu, A Viejo-Borbolla - Virulence, 2021 - Taylor & Francis
Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

History and progress of hypotheses and clinical trials for Alzheimer's disease

PP Liu, Y **e, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies

JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery

B Bai, D Vanderwall, Y Li, X Wang, S Poudel… - Molecular …, 2021 - Springer
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein
posttranslational modifications (PTMs) in Alzheimer's disease (AD). Here we review the …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease

JY Hur, GR Frost, X Wu, C Crump, SJ Pan, E Wong… - Nature, 2020 - nature.com
Innate immunity is associated with Alzheimer's disease, but the influence of immune
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …

COVID‐19 and dementia: analyses of risk, disparity, and outcomes from electronic health records in the US

QQ Wang, PB Davis, ME Gurney… - Alzheimer's & Dementia, 2021 - Wiley Online Library
Introduction At present, there is limited data on the risks, disparity, and outcomes for COVID‐
19 in patients with dementia in the United States. Methods This is a retrospective case …