Mechanochemistry: A green approach in the preparation of pharmaceutical cocrystals
M Solares-Briones, G Coyote-Dotor, JC Páez-Franco… - Pharmaceutics, 2021 - mdpi.com
Mechanochemistry is considered an alternative attractive greener approach to prepare
diverse molecular compounds and has become an important synthetic tool in different fields …
diverse molecular compounds and has become an important synthetic tool in different fields …
An outlook on permeability escalation through cocrystallization for develo** pharmaceuticals with improved biopharmaceutical properties
Permeability of any pharmaceutical is critically significant for its biopharmaceutical profile,
therapeutic activities, and deciding its dosing regimen. Approximately 35% of the marketed …
therapeutic activities, and deciding its dosing regimen. Approximately 35% of the marketed …
Enhanced phytoremediation of Metal (loid) s via spiked ZVI nanoparticles: An urban clean-up strategy with ornamental plants
The increasing industrialization and urbanization are also triggering environmental
pollution, mostly unnoticed, in the case of soil pollution due to uncontrolled contamination by …
pollution, mostly unnoticed, in the case of soil pollution due to uncontrolled contamination by …
Progress on cocrystallization of poorly soluble NME's in the last decade
For tailoring the physicochemical properties of active pharmaceutical ingredients,
cocrystallization has been an exciting field of interest to the researchers. As in recent years …
cocrystallization has been an exciting field of interest to the researchers. As in recent years …
Directed Self-Assembly with Gallic Acid Provides First Phenolic Acid Cocrystals for the Antiviral Drug Acyclovir toward Increasing Pharmaceutical Features and …
FZ Bu, YM Yu, M Zhang, CW Yan, ZY Wu… - Crystal Growth & …, 2023 - ACS Publications
To achieve new breakthroughs in the development of synergistic antiviral medication
cocrystals of acyclovir (AYL) with phenolic acids, a cocrystallization-driven strategy for …
cocrystals of acyclovir (AYL) with phenolic acids, a cocrystallization-driven strategy for …
Molecular complexes of drug combinations: a review of cocrystals, salts, coamorphous systems and amorphous solid dispersions
As the advancements in the medical technology and healthcare develop through the years,
combinational therapy has evolved to be an important treatment modality in many disease …
combinational therapy has evolved to be an important treatment modality in many disease …
Challenges and progress in nonsteroidal anti-inflammatory drugs co-crystal development
I Nugrahani, RD Parwati - Molecules, 2021 - mdpi.com
Co-crystal innovation is an opportunity in drug development for both scientists and industry.
In line with the “green pharmacy” concept for obtaining safer methods and advanced …
In line with the “green pharmacy” concept for obtaining safer methods and advanced …
Novel drug-drug salts of enoxacin with enhanced antibacterial activity: Insights from solubility and lipid-water partition coefficient
J Li, S Song, W Huang, H Fan, Z Zhou - Journal of Molecular Liquids, 2023 - Elsevier
Abstract Enoxacin (ENX), a third-generation fluoroquinolone, demonstrates broad-spectrum
antibacterial activities and is widely applied for the treatment of various bacterial infections …
antibacterial activities and is widely applied for the treatment of various bacterial infections …
Cocrystallization of trimethoprim and solubility enhancement via salt formation
Trimethoprim (TMP) is an active pharmaceutical ingredient with poor aqueous solubility.
Here, we describe the cocrystallization of TMP with five co-formers, three bipyridines and …
Here, we describe the cocrystallization of TMP with five co-formers, three bipyridines and …
Cocrystallization-driven double-optimized stratagem toward directional self-assembly for the first ternary salt cocrystal of cardiotonic drug milrinone with different …
SS Meng, YM Yu, FZ Bu, CW Yan, ZY Wu… - Molecular …, 2023 - ACS Publications
The current research leverages the structural features and property superiorities along with
benefits in protecting cardiovascular system of gallic acid (GLC) and gentisic acid (HGA) to …
benefits in protecting cardiovascular system of gallic acid (GLC) and gentisic acid (HGA) to …