Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one
billion people globally, and causes illness in one million people each year. Caused by …

Scrub typhus and the rickettsial diseases represent some of the oldest recognized vector-
transmitted diseases, fraught with a rich historical aspect, particularly as applied to …

Introduction: Doxycycline is highly effective, inexpensive with a broad therapeutic spectrum
and exceptional bioavailability. However these benefits have been overshadowed by its …

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Rickettsial diseases, caused by a variety of obligate intracellular, Gram-negative bacteria
from the genera Rickettsia, Orientia, Ehrlichia, Neorickettsia, Neoehrlichia, and Anaplasma …

The escalating global consumption of tetracyclines (TCs) as broad-spectrum antibiotics
necessitates innovative approaches to mitigate their pervasive environmental persistence …

Background The appropriate antibiotic treatment for severe scrub typhus, a neglected but
widespread reemerging zoonotic infection, is unclear. Methods In this multicenter, double …

OBJECTIVE: To study the clinical profile of and complications in children with scrub typhus.
DESIGN: Prospective observational study. SETTING: Tertiary care hospital. METHODS …

Rickettsial infections represent a major cause of non-malarial febrile illnesses among the
residents of Southeast Asia and returned travelers from that region. There are several …

Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …