Natural products and their analogues acting against Mycobacterium tuberculosis: A recent update
G Kumar - Drug Development Research, 2023 - Wiley Online Library
Tuberculosis (TB) remains one of the deadliest infectious diseases caused by
Mycobacterium tuberculosis (M. tb). It is responsible for significant causes of mortality and …
Mycobacterium tuberculosis (M. tb). It is responsible for significant causes of mortality and …
Tryptanthrins as multi-bioactive agents: discovery, diversity distribution and synthesis
K Alam, MS Hossain, Y Zhao, Z Zhang, S Xu, J Hao… - Bioorganic …, 2024 - Elsevier
Tryptanthrin and its derivatives, representing a type of alkaloids with indoloquinazoline
structures, were first obtained from blue plants and indigo, and then extracted from fungi …
structures, were first obtained from blue plants and indigo, and then extracted from fungi …
Novel Derivatives of Quinoxaline-2-carboxylic Acid 1, 4-Dioxides as Antimycobacterial Agents: Mechanistic Studies and Therapeutic Potential
The World Health Organization (WHO) reports that tuberculosis (TB) is one of the top 10
leading causes of global mortality. The increasing incidence of multidrug-resistant TB …
leading causes of global mortality. The increasing incidence of multidrug-resistant TB …
The Antitubercular Activities of Natural Products with Fused-Nitrogen-Containing Heterocycles
Tuberculosis (TB) is notorious as the leading cause of death worldwide due to a single
infectious entity and its causative agent, Mycobacterium tuberculosis (Mtb), has been able to …
infectious entity and its causative agent, Mycobacterium tuberculosis (Mtb), has been able to …
Synthesis and characterization of novel 2-acyl-3-trifluoromethylquinoxaline 1, 4-dioxides as potential antimicrobial agents
The emergence of drug resistance in pathogens leads to a loss of effectiveness of
antimicrobials and complicates the treatment of bacterial infections. Quinoxaline 1, 4 …
antimicrobials and complicates the treatment of bacterial infections. Quinoxaline 1, 4 …
Polymeric nanoparticles as a promising drug delivery platform for the efficacious delivery of toll-like receptor 7/8 agonists and IDO-inhibitor
The current investigation delineates the poly (lactide-co-glycolic acid) nanoparticles (PLGA
NPs) formulation as the drug encapsulating assembly using nanoprecipitation method …
NPs) formulation as the drug encapsulating assembly using nanoprecipitation method …
Recent advances of tryptanthrin and its derivatives as potential anticancer agents
X Zhou - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
Tryptanthrin is one of the well-known natural alkaloids with the broader spectrum of
biological activities as anti-inflammatory, anticancer, antibacterial, antifungal, antiviral …
biological activities as anti-inflammatory, anticancer, antibacterial, antifungal, antiviral …
Repurposing Based Identification of Novel Inhibitors against MmpS5-MmpL5 Efflux Pump of Mycobacterium smegmatis: A Combined In Silico and In Vitro Study
In the current era of a pandemic, infections of COVID-19 and Tuberculosis (TB) enhance the
detrimental effects of both diseases in suffering individuals. The resistance mechanisms …
detrimental effects of both diseases in suffering individuals. The resistance mechanisms …
Genetic interaction between F‐box motif encoding YDR131C and retrograde signaling‐related RTG1 regulates the stress response and apoptosis in Saccharomyces …
H Shoket, M Pandita, M Sharma… - … of Biochemical and …, 2021 - Wiley Online Library
The retrograde signaling pathway is well conserved from yeast to humans, which regulates
cell adaptation during stress conditions and prevents cell death. One of its components …
cell adaptation during stress conditions and prevents cell death. One of its components …
Transcriptomic Profile of Mycobacterium smegmatis in Response to an Imidazo[1,2-b][1,2,4,5]tetrazine Reveals Its Possible Impact on Iron Metabolism
AA Vatlin, EA Shitikov, M Shahbaaz… - Frontiers in …, 2021 - frontiersin.org
Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex bacteria, is one of
the most pressing health problems. The development of new drugs and new therapeutic …
the most pressing health problems. The development of new drugs and new therapeutic …