Occupational noise exposure accounts for approximately 16% of all disabling hearing
losses, but the true value and societal costs may be grossly underestimated because current …

Sound therapies are a common component of treatments for tinnitus and hyperacusis. The
original idea was to partially or completely mask tinnitus with broadband noise delivered by …

Neurons in sensory cortex exhibit a remarkable capacity to maintain stable firing rates
despite large fluctuations in afferent activity levels. However, sudden peripheral …

Autism spectrum disorder (ASD) is characterized by social interaction and communication
impairments, as well as restrictive/repetitive patterns of behavior, interests or activities, which …

Autism spectrum disorders (ASD) are strongly associated with auditory hypersensitivity or
hyperacusis (difficulty tolerating sounds). Fragile X syndrome (FXS), the most common …

Hyperacusis is a debilitating loudness intolerance disorder that can evoke annoyance, fear
and aural facial pain. Although the auditory system seems to be the “central” player …

The central gain model of hyperacusis proposes that loss of auditory input can result in
maladaptive neuronal gain increases in the central auditory system, leading to the over …

Abstract Objective: This article reviews:(1) the evidence related to enhanced central gain as
a potential mechanism for the generation of tinnitus and hyperacusis,(2) the neuroplastic …

Noise-induced hearing loss generally induces loudness recruitment, but sometimes gives
rise to hyperacusis, a debilitating condition in which moderate intensity sounds are …

Sensorineural hearing loss (SNHL), sometimes accompanied with tinnitus, is associated
with dysfunctions within and outside the classical auditory pathway. The salience network …