Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis

O Al-Massadi, C Dieguez, M Schneeberger… - Nature Reviews …, 2021 - nature.com
Melanin-concentrating hormone (MCH) is a small cyclic peptide expressed in all mammals,
mainly in the hypothalamus. MCH acts as a robust integrator of several physiological …

[HTML][HTML] Genomics and genetics in the biology of adaptation to exercise

C Bouchard, T Rankinen… - Comprehensive Physiology, 2011 - ncbi.nlm.nih.gov
This chapter is devoted to the role of genetic variation and gene-exercise interactions in the
biology of adaptation to exercise. There is evidence from genetic epidemiology research that …

The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload

J Backs, T Backs, S Neef… - Proceedings of the …, 2009 - National Acad Sciences
Acute and chronic injuries to the heart result in perturbation of intracellular calcium
signaling, which leads to pathological cardiac hypertrophy and remodeling …

Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep–wake cycle

OK Hassani, MG Lee, BE Jones - Proceedings of the …, 2009 - National Acad Sciences
Neurons containing melanin-concentrating hormone (MCH) are codistributed with neurons
containing orexin (Orx or hypocretin) in the lateral hypothalamus, a peptide and region …

Opposing effects of adiponectin receptors 1 and 2 on energy metabolism

M Bjursell, A Ahnmark, M Bohlooly-Y… - Diabetes, 2007 - Am Diabetes Assoc
The adipocyte-derived hormone adiponectin regulates glucose and lipid metabolism and
influences the risk for develo** obesity, type 2 diabetes, and cardiovascular disease …

Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria

I Gramaglia, P Sobolewski, D Meays, R Contreras… - Nature medicine, 2006 - nature.com
The role of nitric oxide (NO) in the genesis of cerebral malaria is controversial. Most
investigators propose that the unfortunate consequence of the high concentrations of NO …

Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety

R Noseda, V Kainz, D Borsook, R Burstein - PLoS One, 2014 - journals.plos.org
Dynamic thalamic regulation of sensory signals allows the cortex to adjust better to rapidly
changing behavioral, physiological and environmental demands. To fulfill this role, thalamic …

Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice

R Vetrivelan, D Kong, LL Ferrari, E Arrigoni, JC Madara… - Neuroscience, 2016 - Elsevier
Currently available evidence indicates that neurons containing melanin-concentrating
hormone (MCH) in the lateral hypothalamus are critical modulators of sleep-wakefulness …

Central control of thermogenesis

JC Clapham - Neuropharmacology, 2012 - Elsevier
In mammals and birds, conservation of body heat at around 37° C is vital to life.
Thermogenesis is the production of this heat which can be obligatory, as in basal metabolic …

The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat

P Fort, D Salvert, L Hanriot, S Jego, H Shimizu… - Neuroscience, 2008 - Elsevier
Overlapped in the tuberal hypothalamic area (THA), melanin-concentrating hormone (MCH)
and hypocretin (Hcrt) neurons contribute to the integrated regulation of food intake, energy …