Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis
Melanin-concentrating hormone (MCH) is a small cyclic peptide expressed in all mammals,
mainly in the hypothalamus. MCH acts as a robust integrator of several physiological …
mainly in the hypothalamus. MCH acts as a robust integrator of several physiological …
[HTML][HTML] Genomics and genetics in the biology of adaptation to exercise
C Bouchard, T Rankinen… - Comprehensive Physiology, 2011 - ncbi.nlm.nih.gov
This chapter is devoted to the role of genetic variation and gene-exercise interactions in the
biology of adaptation to exercise. There is evidence from genetic epidemiology research that …
biology of adaptation to exercise. There is evidence from genetic epidemiology research that …
The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload
J Backs, T Backs, S Neef… - Proceedings of the …, 2009 - National Acad Sciences
Acute and chronic injuries to the heart result in perturbation of intracellular calcium
signaling, which leads to pathological cardiac hypertrophy and remodeling …
signaling, which leads to pathological cardiac hypertrophy and remodeling …
Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep–wake cycle
Neurons containing melanin-concentrating hormone (MCH) are codistributed with neurons
containing orexin (Orx or hypocretin) in the lateral hypothalamus, a peptide and region …
containing orexin (Orx or hypocretin) in the lateral hypothalamus, a peptide and region …
Opposing effects of adiponectin receptors 1 and 2 on energy metabolism
M Bjursell, A Ahnmark, M Bohlooly-Y… - Diabetes, 2007 - Am Diabetes Assoc
The adipocyte-derived hormone adiponectin regulates glucose and lipid metabolism and
influences the risk for develo** obesity, type 2 diabetes, and cardiovascular disease …
influences the risk for develo** obesity, type 2 diabetes, and cardiovascular disease …
Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria
I Gramaglia, P Sobolewski, D Meays, R Contreras… - Nature medicine, 2006 - nature.com
The role of nitric oxide (NO) in the genesis of cerebral malaria is controversial. Most
investigators propose that the unfortunate consequence of the high concentrations of NO …
investigators propose that the unfortunate consequence of the high concentrations of NO …
Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety
R Noseda, V Kainz, D Borsook, R Burstein - PLoS One, 2014 - journals.plos.org
Dynamic thalamic regulation of sensory signals allows the cortex to adjust better to rapidly
changing behavioral, physiological and environmental demands. To fulfill this role, thalamic …
changing behavioral, physiological and environmental demands. To fulfill this role, thalamic …
Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice
Currently available evidence indicates that neurons containing melanin-concentrating
hormone (MCH) in the lateral hypothalamus are critical modulators of sleep-wakefulness …
hormone (MCH) in the lateral hypothalamus are critical modulators of sleep-wakefulness …
Central control of thermogenesis
JC Clapham - Neuropharmacology, 2012 - Elsevier
In mammals and birds, conservation of body heat at around 37° C is vital to life.
Thermogenesis is the production of this heat which can be obligatory, as in basal metabolic …
Thermogenesis is the production of this heat which can be obligatory, as in basal metabolic …
The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat
P Fort, D Salvert, L Hanriot, S Jego, H Shimizu… - Neuroscience, 2008 - Elsevier
Overlapped in the tuberal hypothalamic area (THA), melanin-concentrating hormone (MCH)
and hypocretin (Hcrt) neurons contribute to the integrated regulation of food intake, energy …
and hypocretin (Hcrt) neurons contribute to the integrated regulation of food intake, energy …