The control of inflammation is strictly regulated to ensure the adequate intensity and duration
of an inflammatory response, enabling the removal of the trigger factors and the restoration …

Vitamin K, an essential nutrient often associated with the clotting cascade, has been the
focus of considerable research demonstrating an anticancer potential. Much of this research …

The development and implementation of Immune Checkpoint Inhibitors (ICI) in clinical
oncology have significantly improved the survival of a subset of cancer patients with …

Gas6 is able to inhibit pro-inflammatory cytokine secretion by macrophages acting on Mer
receptor; the pathway involved is mediated by PI3K, Akt, GSK3β, and NFκB. GAS6 protein …

Recent advances in the discovery of new functions for vitamin K‐dependent (VKD) proteins
and in defining vitamin K nutriture have led to a substantial revision in our understanding of …

Axl is a tyrosine kinase receptor and although it is expressed in malignancy such as
leukemia, colon cancer, melanoma, endometrial, prostate and thyroid cancers, its role has …

A focus of contemporary cancer therapeutic development is the targeting of both the
transformed cell and the supporting cellular microenvironment. Cell migration is a …

The role of Gas6 in endothelial cell (EC) function remains incompletely characterized. Here
we report that Gas6 amplifies EC activation in response to inflammatory stimuli in vitro. In …

Abstract Tyro3, Axl, and Mertk, referred to as the TAM family of receptor tyrosine kinases, are
instrumental in maintaining cell survival and homeostasis in mammals. TAM receptors …

Axl is a receptor tyrosine kinase (RTK) with oncogenic potential and transforming activity.
Since Axl bears structural similarities to cell adhesion molecules such as neural cell …