Diabesity is a term used to describe the combined adverse health effects of obesity and
diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an …

Mitochondrial dysfunction has been implicated in the development of heart failure. Oxidative
metabolism in mitochondria is the main energy source of the heart, and the inability to …

The network for cardiac fuel metabolism contains intricate sets of interacting pathways that
result in both ATP-producing and non–ATP-producing end points for each class of energy …

There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

The alterations in myocardial energy substrate metabolism that occur in heart failure, and
the causes and consequences of these abnormalities, are poorly understood. There is …

In patients with diabetes, an increased risk of symptomatic heart failure usually develops in
the presence of hypertension or ischemic heart disease. However, a predisposition to heart …

Background: The failing heart is traditionally described as metabolically inflexible and
oxygen starved, causing energetic deficit and contractile dysfunction. Current metabolic …

The chronically failing heart has been shown to be metabolically abnormal, in both animal
models and in patients. Little data are available on the rate of myocardial glucose, lactate …

As obesity and type 2 diabetes are becoming an epidemic in westernized countries, the
incidence and prevalence of obesity-and diabetes-related co-morbidities are increasing. In …

Significance: Over-nutrition and sedentary lifestyle has led to a worldwide increase in
obesity, insulin resistance, and type 2 diabetes (T2D) associated with an increased risk of …