CRISPR-powered strategies for amplification-free diagnostics of infectious diseases

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Y Liu, Z Chao, W Ding, T Fang, X Gu, M Xue… - Cellular & molecular …, 2024 - Springer
Persistent infection with high-risk human papillomavirus (HR-HPV) is the primary and
initiating factor for cervical cancer. With over 200 identified HPV types, including 14 high-risk …

Recent advances in molecular and immunological diagnostic platform for virus detection: A review

KTL Trinh, HDK Do, NY Lee - Biosensors, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an ongoing
coronavirus disease (COVID-19) outbreak and a rising demand for the development of …

Recent developments toward microfluidic point-of-care diagnostic sensors for viral infections

KZ Mousaabadi, ZT Vandishi, M Kermani… - TrAC Trends in …, 2023 - Elsevier
This review article provides an overview of the application of microfluidics in point-of-care
(POC) diagnostics, with a focus on rapid viral infection diagnosis. The introduction defines …

Empowering the on-site detection of nucleic acids by integrating CRISPR and digital signal processing

CY Lee, H Kim, I Degani, H Lee, A Sandoval… - Nature …, 2024 - nature.com
Addressing the global disparity in cancer care necessitates the development of rapid and
affordable nucleic acid (NA) testing technologies. This need is particularly critical for cervical …

Machine Learning-Assisted, Dual-Channel CRISPR/Cas12a Biosensor-In-Microdroplet for Amplification-Free Nucleic Acid Detection for Food Authenticity Testing

Z Zhao, R Wang, X Yang, J Jia, Q Zhang, S Ye, S Man… - ACS …, 2024 - ACS Publications
The development of novel detection technology for meat species authenticity is imperative.
Here, we developed a machine learning-supported, dual-channel biosensor-in-microdroplet …

Portable, and ultrasensitive HR-HPV tests based on nucleic acid biosensors

C Ma, M Zou, N Xu, Y Liu, Y Wang - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
Cervical cancer is the third most common cancer threatening women's health globally, and
high-risk human papillomavirus (HR-HPV) infection is the main cause of cervical cancer …

CRISPR for companion diagnostics in low-resource settings

Q Xu, Q Xu, C Lyon, TY Hu - Lab on a Chip, 2024 - pubs.rsc.org
New point-of-care tests (POCTs), which are especially useful in low-resource settings, are
needed to expand screening capacity for diseases that cause significant mortality …