One of the great strengths of the mouse model is the wide array of genetic tools that have
been developed. Striking examples include methods for directed modification of the …

Human development has been studied for over a century, but the molecular mechanisms
underlying human embryogenesis remain largely unknown due to technical difficulties and …

Monkeys serve as important model species for studying human diseases and develo**
therapeutic strategies, yet the application of monkeys in biomedical researches has been …

SIRT6 acts as a longevity protein in rodents,. However, its biological function in primates
remains largely unknown. Here we generate a SIRT6-null cynomolgus monkey (Macaca …

Recent advances in gene editing technology have introduced the potential for application of
mutagenesis approaches in nonhuman primates to model human development and …

Many human genetic diseases, including Hutchinson-Gilford progeria syndrome (HGPS),
are caused by single point mutations. HGPS is a rare disorder that causes premature aging …

Transgenic systems are widely used to study the cellular and molecular basis of human
neurodegenerative diseases. A wide variety of model organisms have been utilized …

Tree shrews have a close relationship to primates and have many advantages over rodents
in biomedical research. However, the lack of gene manipulation methods has hindered the …

Parkinson's disease (PD) is an age-dependent neurodegenerative disease that can be
caused by genetic mutations in α-synuclein (α-syn) or duplication of wild-type α-syn; PD is …