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Predicting the effects of amino acid substitutions on protein function
PC Ng, S Henikoff - Annu. Rev. Genomics Hum. Genet., 2006 - annualreviews.org
Nonsynonymous single nucleotide polymorphisms (nsSNPs) are coding variants that
introduce amino acid changes in their corresponding proteins. Because nsSNPs can affect …
introduce amino acid changes in their corresponding proteins. Because nsSNPs can affect …
Analyzing effects of naturally occurring missense mutations
Z Zhang, MA Miteva, L Wang… - … mathematical methods in …, 2012 - Wiley Online Library
Single‐point mutation in genome, for example, single‐nucleotide polymorphism (SNP) or
rare genetic mutation, is the change of a single nucleotide for another in the genome …
rare genetic mutation, is the change of a single nucleotide for another in the genome …
CASTp: computed atlas of surface topography of proteins with structural and topographical map** of functionally annotated residues
J Dundas, Z Ouyang, J Tseng, A Binkowski… - Nucleic acids …, 2006 - academic.oup.com
Cavities on a proteins surface as well as specific amino acid positioning within it create the
physicochemical properties needed for a protein to perform its function. CASTp (http://cast …
physicochemical properties needed for a protein to perform its function. CASTp (http://cast …
SNPs3D: candidate gene and SNP selection for association studies
Background The relationship between disease susceptibility and genetic variation is
complex, and many different types of data are relevant. We describe a web resource and …
complex, and many different types of data are relevant. We describe a web resource and …
Many amino acid substitution variants identified in DNA repair genes during human population screenings are predicted to impact protein function
T **, IM Jones, HW Mohrenweiser - Genomics, 2004 - Elsevier
Over 520 different amino acid substitution variants have been previously identified in the
systematic screening of 91 human DNA repair genes for sequence variation. Two algorithms …
systematic screening of 91 human DNA repair genes for sequence variation. Two algorithms …
LS-SNP: large-scale annotation of coding non-synonymous SNPs based on multiple information sources
Abstract Motivation: The NCBI dbSNP database lists over 9 million single nucleotide
polymorphisms (SNPs) in the human genome, but currently contains limited annotation …
polymorphisms (SNPs) in the human genome, but currently contains limited annotation …
[BOK][B] Advances in protein chemistry and structural biology
R Donev - 2024 - books.google.com
Advances in Protein Chemistry and Structural Biology, Volume 138 covers reviews of
methodology and research in all aspects of protein chemistry, including …
methodology and research in all aspects of protein chemistry, including …
Use of long term molecular dynamics simulation in predicting cancer associated SNPs
Computational prediction of cancer associated SNPs from the large pool of SNP dataset is
now being used as a tool for detecting the probable oncogenes, which are further examined …
now being used as a tool for detecting the probable oncogenes, which are further examined …
Bioinformatics approaches and resources for single nucleotide polymorphism functional analysis
S Mooney - Briefings in bioinformatics, 2005 - academic.oup.com
Since the initial sequencing of the human genome, many projects are underway to
understand the effects of genetic variation between individuals. Predicting and …
understand the effects of genetic variation between individuals. Predicting and …
Modeling effects of human single nucleotide polymorphisms on protein-protein interactions
A large set of three-dimensional structures of 264 protein-protein complexes with known
nonsynonymous single nucleotide polymorphisms (nsSNPs) at the interface was built using …
nonsynonymous single nucleotide polymorphisms (nsSNPs) at the interface was built using …