[HTML][HTML] Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …
neurodegenerative disorders that are thought to exist on a clinical and pathological …
Progranulin, lysosomal regulation and neurodegenerative disease
The discovery that heterozygous and homozygous mutations in the gene encoding
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …
progranulin are causally linked to frontotemporal dementia and lysosomal storage disease …
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB
The view of the lysosome as the terminal end of cellular catabolic pathways has been
challenged by recent studies showing a central role of this organelle in the control of cell …
challenged by recent studies showing a central role of this organelle in the control of cell …
Progranulin deficiency promotes circuit-specific synaptic pruning by microglia via complement activation
H Lui, J Zhang, SR Makinson, MK Cahill, KW Kelley… - Cell, 2016 - cell.com
Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …
GeneMANIA prediction server 2013 update
K Zuberi, M Franz, H Rodriguez, J Montojo… - Nucleic acids …, 2013 - academic.oup.com
Abstract GeneMANIA (http://www. genemania. org) is a flexible user-friendly web interface
for generating hypotheses about gene function, analyzing gene lists and prioritizing genes …
for generating hypotheses about gene function, analyzing gene lists and prioritizing genes …
The lysosomal function of progranulin, a guardian against neurodegeneration
Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor
implicated in a multitude of processes ranging from regulation of inflammation to wound …
implicated in a multitude of processes ranging from regulation of inflammation to wound …
Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
The discovery of potent inhibitors of the BRAF proto-oncogene has revolutionized therapy
for melanoma harboring mutations in BRAF, yet NRAS-mutant melanoma remains without …
for melanoma harboring mutations in BRAF, yet NRAS-mutant melanoma remains without …
Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map
The application of RNA interference (RNAi) to mammalian cells has provided the means to
perform phenotypic screens to determine the functions of genes. Although RNAi has …
perform phenotypic screens to determine the functions of genes. Although RNAi has …
[HTML][HTML] Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortex
Complex network topology is characteristic of many biological systems, including anatomical
and functional brain networks (connectomes). Here, we first constructed a structural …
and functional brain networks (connectomes). Here, we first constructed a structural …
Polymer folding through active processes recreates features of genome organization
From proteins to chromosomes, polymers fold into specific conformations that control their
biological function. Polymer folding has long been studied with equilibrium thermodynamics …
biological function. Polymer folding has long been studied with equilibrium thermodynamics …