Biomedical polymers: synthesis, properties, and applications

WH Chen, QW Chen, Q Chen, C Cui, S Duan… - Science China …, 2022 - Springer
Biomedical polymers have been extensively developed for promising applications in a lot of
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …

Polymeric Nanoparticles for Drug Delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024 - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Polymer-locking fusogenic liposomes for glioblastoma-targeted siRNA delivery and CRISPR–Cas gene editing

Y Zhao, J Qin, D Yu, Y Liu, D Song, K Tian… - Nature …, 2024 - nature.com
In patients with glioblastoma (GBM), upregulated midkine (MDK) limits the survival benefits
conferred by temozolomide (TMZ). RNA interference (RNAi) and CRISPR–Cas9 gene …

Membrane‐Fusion‐Mediated Multiplex Engineering of Tumor Cell Surface Glycans for Enhanced NK Cell Therapy

C Zheng, Q Zhong, W Song, K Yi, H Kong… - Advanced …, 2023 - Wiley Online Library
Natural killer (NK) cell therapies show potential for tumor treatment but are immunologically
resisted by the overexpressed immunosuppressing tumor cell surface glycans. To reverse …

[HTML][HTML] NK cell-based tumor immunotherapy

H Zhang, L Yang, T Wang, Z Li - Bioactive materials, 2024 - Elsevier
Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-
infected cells and tumor cells. They are particularly powerful for elimination of hematological …

Macrocyclic‐Amphiphile‐Based Self‐Assembled Nanoparticles for Ratiometric Delivery of Therapeutic Combinations to Tumors

Z Zhang, YX Yue, L Xu, Y Wang, WC Geng… - Advanced …, 2021 - Wiley Online Library
Combination chemotherapy refers to the use of multiple drugs to treat cancer. In this therapy,
the optimal ratio of the drugs is essential to achieve drug synergism and the desired …

Virus-like nanoparticle as a co-delivery system to enhance efficacy of CRISPR/Cas9-based cancer immunotherapy

Q Liu, C Wang, Y Zheng, Y Zhao, Y Wang, J Hao… - Biomaterials, 2020 - Elsevier
Abstract The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-
associated protein 9 (Cas9) system holds great promise for the cancer gene therapy …

Unleashing natural killer cells in the tumor microenvironment–the next generation of immunotherapy?

A Ben-Shmuel, G Biber, M Barda-Saad - Frontiers in immunology, 2020 - frontiersin.org
The emergence of immunotherapy for cancer treatment bears considerable clinical promise.
Nevertheless, many patients remain unresponsive, acquire resistance, or suffer dose …

[HTML][HTML] Immune-regulating camouflaged nanoplatforms: A promising strategy to improve cancer nano-immunotherapy

BQ Chen, Y Zhao, Y Zhang, YJ Pan, HY **a… - Bioactive Materials, 2023 - Elsevier
Although nano-immunotherapy has advanced dramatically in recent times, there remain two
significant hurdles related to immune systems in cancer treatment, such as (namely) …

An intracellular self‐assembly‐driven uninterrupted ROS generator augments 5‐aminolevulinic‐acid‐based tumor therapy

J Shi, W Nie, X Zhao, X Yang, H Cheng… - Advanced …, 2022 - Wiley Online Library
Free radical therapy based on 5‐aminolevulinic acid (ALA, a precursor of the
photosensitizer protoporphyrin IX (PpIX)) has been approved by the US Food and Drug …