Conspectus The distribution of the electron density around covalently bonded atoms is
anisotropic, and this determines the presence, on atoms surface, of areas of higher and …

The halogen bond occurs when there is evidence of a net attractive interaction between an
electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic …

Halogen bonding, the noncovalent interaction based on electrophilic halogen substituents,
features very interesting properties, as illustrated by numerous applications continuously …

The founding in 1965 of what is now called the Cambridge Structural Database (CSD) has
reaped dividends in numerous and diverse areas of chemical research. Each of the million …

A covalently-bonded atom typically has a region of lower electronic density, a “σ-hole,” on
the side of the atom opposite to the bond, along its extension. There is frequently a positive …

In the field of noncovalent interactions a new paradigm has recently become popular. It
stems from the analysis of molecular electrostatic potentials and introduces a label, which …

The σ-hole and π-hole are the regions with positive surface electrostatic potential on the
molecule entity; the former specifically refers to the positive region of a molecular entity …

Non‐covalent interactions play a crucial role in (supramolecular) chemistry and much of
biology. Supramolecular forces can indeed determine the structure and function of a host …

A σ-hole bond is a noncovalent interaction between a covalently-bonded atom of Groups IV–
VII and a negative site, eg a lone pair of a Lewis base or an anion. It involves a region of …

Halogen bonding has been known in material science for decades, but until recently,
halogen bonds in protein–ligand interactions were largely the result of serendipitous …