Cell stretching devices as research tools: engineering and biological considerations

H Kamble, MJ Barton, M Jun, S Park, NT Nguyen - Lab on a Chip, 2016 - pubs.rsc.org
Cells within the human body are subjected to continuous, cyclic mechanical strain caused
by various organ functions, movement, and growth. Cells are well known to have the ability …

New advances in probing cell–extracellular matrix interactions

AP Liu, O Chaudhuri, SH Parekh - Integrative Biology, 2017 - academic.oup.com
The extracellular matrix (ECM) provides structural and biochemical support to cells within
tissues. An emerging body of evidence has established that the ECM plays a key role in cell …

A microfluidic pipette array for mechanophenoty** of cancer cells and mechanical gating of mechanosensitive channels

LM Lee, AP Liu - Lab on a Chip, 2015 - pubs.rsc.org
Micropipette aspiration measures the mechanical properties of single cells. A traditional
micropipette aspiration system requires a bulky infrastructure and has a low throughput and …

Biomechanical strain exacerbates inflammation on a progeria‐on‐a‐chip model

J Ribas, YS Zhang, PR Pitrez, J Leijten, M Miscuglio… - small, 2017 - Wiley Online Library
Organ‐on‐a‐chip platforms seek to recapitulate the complex microenvironment of human
organs using miniaturized microfluidic devices. Besides modeling healthy organs, these …

Critical frequency and critical stretching rate for reorientation of cells on a cyclically stretched polymer in a microfluidic chip

T Mao, Y He, Y Gu, Y Yang, Y Yu… - ACS Applied Materials …, 2021 - ACS Publications
The ability of cells to sense and respond to mechanical signals from their surrounding
microenvironments is one of the key issues in tissue engineering and regeneration, yet a …

[HTML][HTML] Finite element modeling of factors influencing optic nerve head deformation due to intracranial pressure

AJ Feola, JG Myers, J Raykin, L Mulugeta… - … & visual science, 2016 - arvojournals.org
Purpose: Visual impairment and intracranial pressure (VIIP) syndrome is a health concern
for long-duration spaceflight, and a proposed risk factor is elevation of intracranial pressure …

A microdevice platform for characterizing the effect of mechanical strain magnitudes on the maturation of iPSC-Cardiomyocytes

W Dou, L Wang, M Malhi, H Liu, Q Zhao… - Biosensors and …, 2021 - Elsevier
The use of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) as an
in vitro model of the heart is limited by their structurally and functionally immature …

Deep Learning for Strain Field Customization in Bioreactor with Dielectric Elastomer Actuator Array

J Wang, D Sarkar, A Mohan, M Lee, Z Ma… - Cyborg and Bionic …, 2024 - spj.science.org
In the field of biomechanics, customizing complex strain fields according to specific
requirements poses an important challenge for bioreactor technology, primarily due to the …

Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes

J Kreutzer, M Viehrig, RP Pölönen, F Zhao… - … and Modeling in …, 2020 - Springer
In this paper, we present a transparent mechanical stimulation device capable of uniaxial
stimulation, which is compatible with standard bioanalytical methods used in cellular …

Deformation of the lamina cribrosa and optic nerve due to changes in cerebrospinal fluid pressure

AJ Feola, B Coudrillier, J Mulvihill… - … & visual science, 2017 - iovs.arvojournals.org
Purpose: Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various
ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual …