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Cell stretching devices as research tools: engineering and biological considerations
Cells within the human body are subjected to continuous, cyclic mechanical strain caused
by various organ functions, movement, and growth. Cells are well known to have the ability …
by various organ functions, movement, and growth. Cells are well known to have the ability …
New advances in probing cell–extracellular matrix interactions
The extracellular matrix (ECM) provides structural and biochemical support to cells within
tissues. An emerging body of evidence has established that the ECM plays a key role in cell …
tissues. An emerging body of evidence has established that the ECM plays a key role in cell …
A microfluidic pipette array for mechanophenoty** of cancer cells and mechanical gating of mechanosensitive channels
Micropipette aspiration measures the mechanical properties of single cells. A traditional
micropipette aspiration system requires a bulky infrastructure and has a low throughput and …
micropipette aspiration system requires a bulky infrastructure and has a low throughput and …
Biomechanical strain exacerbates inflammation on a progeria‐on‐a‐chip model
Organ‐on‐a‐chip platforms seek to recapitulate the complex microenvironment of human
organs using miniaturized microfluidic devices. Besides modeling healthy organs, these …
organs using miniaturized microfluidic devices. Besides modeling healthy organs, these …
Critical frequency and critical stretching rate for reorientation of cells on a cyclically stretched polymer in a microfluidic chip
The ability of cells to sense and respond to mechanical signals from their surrounding
microenvironments is one of the key issues in tissue engineering and regeneration, yet a …
microenvironments is one of the key issues in tissue engineering and regeneration, yet a …
[HTML][HTML] Finite element modeling of factors influencing optic nerve head deformation due to intracranial pressure
Purpose: Visual impairment and intracranial pressure (VIIP) syndrome is a health concern
for long-duration spaceflight, and a proposed risk factor is elevation of intracranial pressure …
for long-duration spaceflight, and a proposed risk factor is elevation of intracranial pressure …
A microdevice platform for characterizing the effect of mechanical strain magnitudes on the maturation of iPSC-Cardiomyocytes
The use of human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) as an
in vitro model of the heart is limited by their structurally and functionally immature …
in vitro model of the heart is limited by their structurally and functionally immature …
Deep Learning for Strain Field Customization in Bioreactor with Dielectric Elastomer Actuator Array
In the field of biomechanics, customizing complex strain fields according to specific
requirements poses an important challenge for bioreactor technology, primarily due to the …
requirements poses an important challenge for bioreactor technology, primarily due to the …
Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes
In this paper, we present a transparent mechanical stimulation device capable of uniaxial
stimulation, which is compatible with standard bioanalytical methods used in cellular …
stimulation, which is compatible with standard bioanalytical methods used in cellular …
Deformation of the lamina cribrosa and optic nerve due to changes in cerebrospinal fluid pressure
Purpose: Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various
ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual …
ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual …