[HTML][HTML] Can stemness and chemoresistance be therapeutically targeted via signaling pathways in ovarian cancer?

L Roy, KD Cowden Dahl - Cancers, 2018 - mdpi.com
Ovarian cancer is the most lethal gynecological malignancy. Poor overall survival,
particularly for patients with high grade serous (HGS) ovarian cancer, is often attributed to …

[HTML][HTML] The role of cancer stem cell markers in ovarian cancer

K Frąszczak, B Barczyński - Cancers, 2023 - mdpi.com
Simple Summary This manuscript focuses on cancer stem cells and the diagnostic potential
of selected biomarkers of these cells in ovarian cancers. Ovarian cancer has nonspecific …

[HTML][HTML] Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer

SA Shahin, R Wang, SI Simargi, A Contreras… - … , Biology and Medicine, 2018 - Elsevier
TWIST protein is critical to development and is activated in many cancers. TWIST regulates
epithelial-mesenchymal transition, and is linked to angiogenesis, metastasis, cancer stem …

[HTML][HTML] RBM15‑mediating MDR1 mRNA m6A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer

J Yuan, W Guan, X Li, F Wang… - … Journal of Oncology, 2023 - spandidos-publications.com
Ovarian cancer (OC) lacks effective biomarkers for diagnosis at an early stage and often
develops chemoresistance after the initial treatment at an advanced stage. RNA‑binding …

Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models

CM Roberts, SA Shahin, W Wen, JB Finlay… - … , Biology and Medicine, 2017 - Elsevier
Epithelial ovarian cancer (EOC) is the most deadly gynecologic malignancy on account of its
late stage at diagnosis and frequency of drug resistant recurrences. Novel therapies to …

CD44 expression predicts prognosis of ovarian cancer patients through promoting epithelial-mesenchymal transition (EMT) by regulating snail, ZEB1, and caveolin-1

J Zhou, Y Du, Y Lu, B Luan, C Xu, Y Yu… - Frontiers in oncology, 2019 - frontiersin.org
Objectives: CD44, a transmembrane glycoprotein, is involved in the generation of a stem cell
niche and maintaining stem cell quiescence. The aim of this study was to evaluate its …

Clinicopathological and prognostic significance of cancer stem cell markers in ovarian cancer patients: Evidence from 52 studies

Y Tao, H Li, R Huang, D Mo, T Zeng, M Fang… - Cellular Physiology and …, 2018 - karger.com
Abstract Background/Aims: Relevant markers of cancer stem cells (CSCs) may serve as
commonly used biomarkers of ovarian cancer (OC). However, their actual …

[HTML][HTML] Metabolic plasticity in ovarian cancer stem cells

A Ghoneum, D Gonzalez, AY Abdulfattah, N Said - Cancers, 2020 - mdpi.com
Ovarian Cancer is the fifth most common cancer in females and remains the most lethal
gynecological malignancy as most patients are diagnosed at late stages of the disease …

CD44 as a cancer stem cell marker and its prognostic value in patients with ovarian carcinoma

A Bartakova, K Michalova, J Presl… - Journal of Obstetrics …, 2018 - Taylor & Francis
The aim of our study was to clarify whether the CD44 adhesion molecule as a cancer stem
cell marker could also serve as a prognostic factor in patients with epithelial ovarian cancer …

Effects of CD44 and E‑cadherin overexpression on the proliferation, adhesion and invasion of ovarian cancer cells

M Mao, X Zheng, B **, F Zhang… - Experimental and …, 2017 - spandidos-publications.com
CD44 is a prognostic indicator of shorter survival time in ovarian cancer. E‑cadherin
fragmentation promotes the progression of ovarian cancer. However, the effects of CD44 …