Fluorescence-guided surgery is an intraoperative optical imaging method that provides
surgeons with real-time guidance for the delineation of tumours. Currently, in phase 1 and 2 …

Confocal laser endomicroscopy (CLE) is a promising technology that provides real-time
histological visualization of living tissue, described as “optical biopsy”. It has been used …

Objectives Surgical removal of squamous cell carcinoma of the tongue (SCCT) with tumour-
free margin status (≥ 5 mm) is essential for loco-regional control. Inadequate margins (< 5 …

Simple Summary Laryngeal cancer is a prevalent head and neck malignancy, with poor
prognosis and low survival rates for patients with advanced disease. The recurrence rate for …

Patients with oral cavity cancer are almost always treated with surgery. The goal is to
remove the tumor with a margin of more than 5 mm of surrounding healthy tissue …

With an incidence of 350.000 new cases per year, cancer of the oral cavity ranks among the
10 most common solid organ cancers. Most of these cancers are squamous cell carcinomas …

Surgical removal with negative margins is the preferred management of oral squamous cell
carcinomas. This review summarizes statements by professional organizations and data …

The main challenge for radical resection in oral cancer surgery is to obtain adequate
resection margins. Especially the deep margin, which can only be estimated based on …

Background Image‐guided surgery could help obtain clear (≥ 5.0 mm) resection margins.
This feasibility study investigated ultrasound‐guided resection accuracy of buccal mucosa …

In head and neck cancer, a major limitation of current intraoperative margin analysis is the
ability to detect areas most likely to be positive based on specimen palpation, especially for …