Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Twenty-five years ago, Hancock and Parks asked a provocative question:“what is the true
solubility advantage for amorphous pharmaceuticals?” Difficulties in determining the …

Tailing off release in the sustained release of water-insoluble curcumin (Cur) is a significant
challenge in the drug delivery system. As a novel solution, core–shell nanodrug containers …

Does the performance of an amorphous solid dispersion rely on having 100% amorphous
content? What specifications are appropriate for crystalline content within an amorphous …

Glass transition temperature (T g) is important for amorphous compounds because it can
have implications on their physical and chemical stability. With drugs that possess ionizable …

This manuscript represents the view of the Dissolution Working Group of the IQ Consortium
on the challenges of and recommendations on solubility measurements and development of …

This research demonstrates the influence of laser speed and the drug particle size on the
manufacturing of amorphous solid dispersions (ASD) and dosage forms thereof using …

Amorphous drugs are used to improve bioavailability of poorly water-soluble drugs.
Crystallization must be managed to take full advantage of this formulation strategy …

The application of mesoporous carriers in formulations of amorphous solid dispersions
(ASDs) has been suggested to enhance the stability of amorphous drugs. However …

Most active pharmaceutical ingredients (APIs) suffer from poor water solubility, often kee**
them from reaching patients. To overcome the issues of poor drug solubility and subsequent …