[HTML][HTML] Polymer based sustained drug delivery to the ocular posterior segment: barriers and future opportunities for the treatment of neovascular pathologies

RA Alshaikh, C Waeber, KB Ryan - Advanced Drug Delivery Reviews, 2022 - Elsevier
There is an increasing momentum in research and pharmaceutical industry communities to
design sustained, non-invasive delivery systems to treat chronic neovascular ocular …

[HTML][HTML] Intravitreal therapeutic nanoparticles for age-related macular degeneration: Design principles, progress and opportunities

Y Zhang, S Watson, Y Ramaswamy, G Singh - Advances in Colloid and …, 2024 - Elsevier
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly. The
current standard treatment for AMD involves frequent intravitreal administrations of …

Beyond VEGF: targeting inflammation and other pathways for treatment of retinal disease

A Muniyandi, GD Hartman, Y Song, M Mijit… - The Journal of …, 2023 - Elsevier
Neovascular eye diseases include conditions such as retinopathy of prematurity,
proliferative diabetic retinopathy, and neovascular age-related macular degeneration …

Six-month sustained delivery of anti-VEGF from in-situ forming hydrogel in the suprachoroidal space

JH Jung, SS Kim, H Chung, A Hejri… - Journal of Controlled …, 2022 - Elsevier
Patients with wet age-related macular degeneration (AMD) require intravitreal injections of
bevacizumab (Bev) or other drugs, often on a monthly basis, which is a burden on the …

Particle carriers for controlled release of peptides

EY Jiang, ST Desroches, AG Mikos - Journal of Controlled Release, 2023 - Elsevier
There has been growing discovery and use of therapeutic peptides in drug delivery and
tissue engineering. Peptides are smaller than proteins and can be formulated into drug …

Fabrication, drug delivery kinetics and cell viability assay of PLGA-coated vancomycin-loaded silicate porous microspheres

N Zirak, AM Maadani, E Salahinejad… - Ceramics …, 2022 - Elsevier
Porous ceramic microspheres are a desirable substance for bone tissue reconstruction and
delivery applications. This study focuses on Mg–Ca silicate microspheres encapsulated in …

Nanomaterials in the diagnosis and treatment of ophthalmic diseases

Y Ma, Z Zhang, Y Yu, X Wang, S Liu, B Sun, Z Cai… - Nano Today, 2024 - Elsevier
The complexity of the human eye structure poses challenges in the diagnosis and treatment
of ocular diseases, especially the low efficiency of ocular drug delivery. With the continuous …

A three-dimensional printed polycaprolactone scaffold combined with co-axially electrospun vancomycin/ceftazidime/bone morphological protein-2 sheath-core …

YH Yu, D Lee, YH Hsu, YC Chou… - International journal …, 2020 - Taylor & Francis
Introduction Masquelet proposed a new solution for the healing of segmental bone defects,
thus minimizing the disadvantages associated with traditional bone grafting. However, a …

Enhanced drug carrier capacity after post modification process for amino acid substitute phosphazene based microspheres with anticancer activity

F Ozsoy, O Ozay - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
In this study, drug carrier HCCP-PP-LEEMP microspheres were synthesized by using
Hexachlorocyclotriphosphazene (HCCP), Phenolphthalein (PP) and l-Lysine Ethyl Ester …

Recent Advances in Formulations for Long-Acting Delivery of Therapeutic Peptides

P Sahandi Zangabad… - ACS Applied Bio …, 2023 - ACS Publications
Recent preclinical and clinical studies have focused on the active area of therapeutic
peptides due to their high potency, selectivity, and specificity in treating a broad range of …