Abstract This Consensus Statement summarizes recommendations for clinical diagnosis,
investigation and management of patients with Silver–Russell syndrome (SRS), an …

Children born small for gestational age (SGA), defined as a birth weight and/or length
below− 2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are …

In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2)
knockout mouse models, we have learnt much about the structure of this protein, its role and …

Background Multiple clinical scoring systems have been proposed for Silver-Russell
syndrome (SRS). Here we aimed to test a clinical scoring system for SRS and to analyse the …

In humans, mutations in IGF1 or IGF1R cause intrauterine and postnatal growth restriction;
however, data on mutations in IGF2, encoding insulin-like growth factor (IGF) II, are lacking …

Congenital imprinting disorders (IDs) are characterised by molecular changes affecting
imprinted chromosomal regions and genes, ie genes that are expressed in a parent-of-origin …

The fast technological development, particularly single nucleotide polymorphism array, array-
comparative genomic hybridization, and whole exome sequencing, has led to the discovery …

Context: Genetics plays a major role in determining an individual's height. Although there
are many monogenic disorders that lead to perturbations in growth and result in short …

Purpose Fetal growth is a complex process involving maternal, placental and fetal factors.
The etiology of fetal growth retardation remains unknown in many cases. The aim of this …

Identifying the genetic input for fetal growth will help to understand common, serious
complications of pregnancy such as fetal growth restriction. Genomic imprinting is an …