[HTML][HTML] Stretching the limits of extracellular signal-related kinase (ERK) signaling—cell mechanosensing to ERK activation
Extracellular signal-regulated kinase (ERK) has been recognized as a critical regulator in
various physiological and pathological processes. Extensive research has elucidated the …
various physiological and pathological processes. Extensive research has elucidated the …
[HTML][HTML] Tug-of-war via ERK signaling pathway for tissue organization–ERK activation to force generation
AN Nayak, T Hirashima - Current Opinion in Cell Biology, 2023 - Elsevier
Extracellular signal-regulated kinase (ERK) plays a crucial role in regulating collective cell
behaviors observed in diverse biological phenomena. Emerging studies have shed light on …
behaviors observed in diverse biological phenomena. Emerging studies have shed light on …
Spatially coordinated cell cycle activity and motility govern bifurcation of mammary branches
Branching morphogenesis is an evolutionary solution to maximize epithelial function in a
compact organ. It involves successive rounds of branch elongation and branch point …
compact organ. It involves successive rounds of branch elongation and branch point …
3D cell neighbour dynamics in growing pseudostratified epithelia
During morphogenesis, epithelial sheets remodel into complex geometries. How cells
dynamically organise their contact with neighbouring cells in these tightly packed tissues is …
dynamically organise their contact with neighbouring cells in these tightly packed tissues is …
Fibroblast-induced mammary epithelial branching depends on fibroblast contractility
Epithelial branching morphogenesis is an essential process in living organisms, through
which organ-specific epithelial shapes are created. Interactions between epithelial cells and …
which organ-specific epithelial shapes are created. Interactions between epithelial cells and …
An actin bracket-induced elastoplastic transition determines epithelial folding irreversibility
A Teranishi, M Mori, R Ichiki, S Toda, G Shioi… - Nature …, 2024 - nature.com
During morphogenesis, epithelial sheets undergo sequential folding to form three-
dimensional organ structures. The resulting folds are often irreversible, ensuring that …
dimensional organ structures. The resulting folds are often irreversible, ensuring that …
Spatiotemporal clusters of ERK activity coordinate cytokine-induced inflammatory responses in human airway epithelial cells
NL DeCuzzi, D Oberbauer, KJ Chmiel… - American Journal of …, 2024 - atsjournals.org
Spatially coordinated ERK signaling events (“SPREADs”) transmit radially from a central
point to adjacent cells via secreted ligands for EGFR and other receptors. SPREADs …
point to adjacent cells via secreted ligands for EGFR and other receptors. SPREADs …
3D organisation of cells in pseudostratified epithelia
Pseudostratified epithelia have smooth apical and basal surfaces, yet along the apical-basal
axis, cells assume highly irregular shapes, which we introduce as punakoids. They interact …
axis, cells assume highly irregular shapes, which we introduce as punakoids. They interact …
Local Mechanical Modulation-Driven Evagination in Invaginated Epithelia
X Yin, D Liang, SQ He, LY Zhang, GK Xu - Nano Letters, 2024 - ACS Publications
Local cells can actively create reverse bending (evagination) in invaginated epithelia, which
plays a crucial role in the formation of elaborate organisms. However, the precise physical …
plays a crucial role in the formation of elaborate organisms. However, the precise physical …
The Mechanics of Building Functional Organs
Organ morphogenesis is multifaceted, multiscale, and fundamentally a robust process.
Despite the complex and dynamic nature of embryonic development, organs are built with …
Despite the complex and dynamic nature of embryonic development, organs are built with …