Inflammation is part of our body's response to tissue injury and pathogens. It helps to recruit
various immune cells to the site of inflammation and activates the production of mediators to …

Chronic inflammation has emerged as one of the hallmarks of cancer. Inflammation also
plays a pivotal role in modulating radiation responsiveness of tumors. As discussed in this …

Purpose: Sphingosine kinases (SK1 and SK2) regulate tumor growth by generating the
mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P). This phase I study …

Sphingolipids are components of all eukaryotic cells that play important roles in a wide
variety of biological processes. Ceramides and sphingosine-1-phosphate (S1P) are …

The bioactive sphingolipids ceramide, sphingosine and sphingosine‐1‐phosphate (S1P)
are important signalling molecules that regulate a diverse array of cellular processes. Most …

The sphingolipid family of lipids modulate several cellular processes, including proliferation,
cell cycle regulation, inflammatory signaling pathways, and cell death. Several members of …

Abstract Development of chemoresistance in breast cancer patients greatly increases
mortality. Thus, understanding mechanisms underlying breast cancer resistance to …

Drug resistance continues to be one of the major challenges to cure cancer. As research in
this field evolves, it has been proposed that numerous bioactive molecules might be …

Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from
proliferation to cell death. Sphingolipids are modified in multiple cancers and are …

The NF-kB1 gene belongs to the family of transcription factors that are involved in the
regulation of a wide range of biological reactions. It has been established that NF-kB1 plays …