Solid‐state NMR spectroscopy has become a valuable tool for the characterization of both
pure and formulated active pharmaceutical ingredients (APIs). However, NMR generally …

This perspective contains a brief review of some of the most recent developments in solid-
state NMR spectroscopy of spin I= 1/2 nuclei. Over the last few years, methodological …

Dynamic nuclear polarization (DNP) solid-state NMR has been applied to powdered
microcrystalline solids to obtain sensitivity enhancements on the order of 100. Glucose …

It is shown that molecular structure and dynamics of a uniformly labeled membrane protein
can be studied under magic-angle-spinning conditions. For this purpose, dipolar recoupling …

We introduce a homonuclear version of third spin assisted recoupling, a second-order
mechanism that can be used for polarization transfer between C 13 or N 15 spins in magic …

Dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy at 9.4 T is
demonstrated for the detailed atomic-level characterization of commercial pharmaceutical …

A protocol for the structure determination of powdered solids at natural abundance by NMR
is presented and illustrated for the case of the small drug molecule thymol. The procedure …

Characterization of protein dynamics by solid-state NMR spectroscopy requires robust and
accurate measurement protocols, which are not yet fully developed. In this study, we …

The inability to determine molecular structures from powdered samples is a key barrier to
progress in many areas of molecular and materials science. We report an approach to …

The investigation of 1H− 1H spin-diffusion build-up curves using a rate matrix analysis
approach shows that high-resolution magic angle spinning NMR of protons, applied to …