Candida Infections of the Genitourinary Tract

JM Achkar, BC Fries - Clinical microbiology reviews, 2010‏ - journals.asm.org
All humans are colonized with Candida species, mostly Candida albicans, yet some develop
diseases due to Candida, among which genitourinary manifestations are extremely …

Regulatory circuitry governing fungal development, drug resistance, and disease

RS Shapiro, N Robbins, LE Cowen - Microbiology and molecular …, 2011‏ - journals.asm.org
Pathogenic fungi have become a leading cause of human mortality due to the increasing
frequency of fungal infections in immunocompromised populations and the limited …

A fungal immunotherapeutic vaccine (NDV-3A) for treatment of recurrent vulvovaginal candidiasis—a phase 2 randomized, double-blind, placebo-controlled trial

JE Edwards Jr, MM Schwartz… - Clinical Infectious …, 2018‏ - academic.oup.com
Background Recurrent vulvovaginal candidiasis (RVVC) is a problematic form of mucosal
Candida infection, characterized by repeated episodes per year. Candida albicans is the …

An insight into the antifungal pipeline: selected new molecules and beyond

L Ostrosky-Zeichner, A Casadevall… - Nature reviews Drug …, 2010‏ - nature.com
Invasive fungal infections are increasing in incidence and are associated with substantial
mortality. Improved diagnostics and the availability of new antifungals have revolutionized …

Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells

QT Phan, CL Myers, Y Fu, DC Sheppard… - PLoS …, 2007‏ - journals.plos.org
Candida albicans is the most common cause of hematogenously disseminated and
oropharyngeal candidiasis. Both of these diseases are characterized by fungal invasion of …

Candida albicans Cell Wall Proteins

WLJ Chaffin - Microbiology and molecular biology reviews, 2008‏ - journals.asm.org
The Candida albicans cell wall maintains the structural integrity of the organism in addtion to
providing a physical contact interface with the environment. The major components of the …

A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology

DA Hogan, Å Vik, R Kolter - Molecular microbiology, 2004‏ - Wiley Online Library
Candida albicans is an opportunistic pathogen that is commonly found as a member of the
human microflora. The ability of C. albicans to alter its cellular morphology has been …

Environmental Sensing and Signal Transduction Pathways Regulating Morphopathogenic Determinants of Candida albicans

S Biswas, P Van Dijck, A Datta - Microbiology and molecular …, 2007‏ - journals.asm.org
Candida albicans is an opportunistic fungal pathogen that is found in the normal
gastrointestinal flora of most healthy humans. However, under certain environmental …

CotH3 mediates fungal invasion of host cells during mucormycosis

T Gebremariam, M Liu, G Luo, V Bruno, QT Phan… - The Journal of clinical …, 2014‏ - jci.org
Angioinvasion is a hallmark of mucormycosis. Previously, we identified endothelial cell
glucose-regulated protein 78 (GRP78) as a receptor for Mucorales that mediates host cell …

Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo

CJ Nobile, DR Andes, JE Nett, FJ Smith Jr, F Yue… - PLoS …, 2006‏ - journals.plos.org
The fungal pathogen Candida albicans is frequently associated with catheter-based
infections because of its ability to form resilient biofilms. Prior studies have shown that the …