We leveraged information from more than 1.2 million participants, including 97,383 cases, to
investigate the genetics of anxiety disorders across five continental groups. Through …

Cyclic adenosine monophosphate (cAMP) is an intracellular second messenger that is
derived from the conversion of adenosine triphosphate catalysed by adenylyl cyclase (AC) …

Anxiety disorders are a leading source of human misery, morbidity, and premature mortality.
Existing treatments are far from curative for many, underscoring the need to clarify the …

Large-scale genome-wide association studies (GWASs) have associated intronic variants in
PDE4B, encoding cAMP-specific phosphodiesterase-4B (PDE4B), with increased risk for …

Background The occurrence of post-traumatic stress disorder (PTSD) following a traumatic
event is associated with biological differences that can represent the susceptibility to PTSD …

Current literature suggests that people with psychiatric disorders have a higher risk of
COVID-19 infection and a worse prognosis of the disease. We aimed to study the genetic …

Posttraumatic stress disorder (PTSD) is a complex psychiatric condition that develops in
response to experiencing or witnessing traumatic events. Characterized by symptoms such …

Most of the fear literature on humans and animals tests healthy individuals. However, fear
memories can differ between healthy individuals and those previously exposed to traumatic …

Importance Although psychological traumas have been associated with endometriosis,
limited information is available regarding the role of trauma type and genetic predisposition …

At the 39th meeting of the International Society of Traumatic Stress Studies, four leading
scientists and clinicians were invited to reflect on their careers, focusing on the biological …