The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

Bifunctional squaramides as a branch of organo‐catalysts showed powerful strategies in the
art of asymmetric synthesis, and they have been proved to be highly efficient and versatile …

N-2, 2, 2-Trifluoroethylisatin ketimines with β-trifluoromethyl enones, 3-trifluoroethylidene
oxindole, and 3-trifluoroethylidene benzofuranone can undergo asymmetric [3+ 2] …

For almost 20 years, thioureas have been experiencing a renaissance of interest with the
emerged development of asymmetric organocatalysts. Due to their relatively high acidity and …

The exploitation of the α-trifluoromethylamino group as an amide surrogate in
peptidomimetics and drug candidates has been on the rise. In a large number of these …

The broad prospects of trifluoromethylated compounds in materials science, agricultural
chemistry, and pharmaceutical chemistry have stimulated the rapid development of …

This review summarizes the latest developments in asymmetric domino reactions, with the
emphasis on the preparation of spiro compounds. Discussions on the stereoselectivity of the …

Reported here is an alternative method for asymmetric synthesis of the CF3‐substituted 3,
2′‐pyrrolidinyl spirooxindoles via 1, 3‐dipolar cycloaddition by employing dipeptide‐based …

Squaramide-catalyzed asymmetric domino Michael/Mannich [3+ 2] cycloaddition reaction
between rhodanine derivatives and N-(2, 2, 2-trifluoroethyl) isatin ketimines has been …

Chiral 2, 3-dihydro-4 H-imidazol-4-ones are key motifs in both synthetic and biological
chemistry. However, their accessibility is classically limited to optical resolution of …