Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Abstract The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins
capable of transporting zinc and other heavy metal ions. Involved in metal …

Cadmium is an environmental pollutant and significant health hazard that is similar to the
physiological metal zinc. In Caenorhabditis elegans, high zinc homeostasis is regulated by …

Background Zinc is an essential metal involved in many physiological processes. Previous
work has identified a set of zinc transporters involved in Drosophila dietary zinc absorption …

To explore the joint toxicity and bio-accumulation of multi-heavy metals and potential
chemoprevention strategies, Male Sprague Dawley (SD) rats (n= 30) were treated orally …

Numerous zinc ectoenzymes are metalated by zinc and activated in the compartments of the
early secretory pathway before reaching their destination. Zn transporter (ZNT) proteins …

Homozygous mutations in SLC30A10 cause familial parkinsonism associated with
manganese (Mn) retention. We recently identified SLC30A10 to be a cell surface-localized …

Zinc is an essential trace element that acts as a co-factor for many enzymes and
transcription factors required for cellular growth and development. Altering intracellular zinc …

It is estimated that up to 10% of proteins in eukaryotes require zinc for their function.
Although the majority of these proteins are located in the nucleus and cytosol, a small subset …

Zinc is an essential trace element that is required for the function of a large number of
proteins. As these zinc-binding proteins are found within the cytosol and organelles, all …